Introducing Estrogen Metabolism as the Main Target of Wedelia chinensis in Prostate Cancer Cells

Document Type : Original paper


1 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Traditional Medicine and Materia Medica Research Center and Department of Traditional Medicine, School of Traditional Medicine, Shahid, Beheshti University of Medical Sciences, Tehran, Iran.

3 Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


Background and objectives: Investigations indicate that Wedelia chinensis extract increases efficacy of prostate cancer treatment. In the present study, the differentially expressed genes (DEGs) of prostate cancer cell line 22RV1 in the presence of W. chinensis extract derived from Gene Expression Omnibus (GEO) were evaluated by gene ontology and pathway analysis. Methods: Gene expression profiles of GSE100224 were analyzed by GEO2R. The significant DEGs were assessed via action map analysis. The related biological terms were identified for the significant DEGS. The highlighted dysregulated genes and pathways were discussed. Results: Seventy significant DEGs including 49 up-regulated genes and 21 down-regulated ones were assessed by inhibition, activation, expression, and binding actions. Cytochrome P450 and PTGS2 were highlighted as the crucial DEGs. Estrogen metabolism was pointed as the main targeted pathway.  Conclusion: Findings indicated that “estrogen metabolism” and UGT1A1, MAOA, PTSG2, and cytochrome P450 in the 22RV1 cells were the main targeted pathway and genes by W. chinensis .


Main Subjects

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