Traditional and Recent Evidence on Five Phytopharmaceuticals from Rosa damascena Herrm.

Document Type : Review


1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Department of Phytopharmaceuticals (Traditional Pharmacy), Shiraz University of Medical Sciences, Shiraz, Iran.

3 Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

4 Department of Phytopharmaceuticals (Traditional Pharmacy), Shiraz University of Medical Sciences, Shiraz, Iran.Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

5 Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran.


Damask rose or Rosa damascena Herrm. is one of the most widely-used medicinal herbs in Iranian Traditional Medicine (ITM). Because of different types of phytochemicals such as flavonoids, glycosides, terpenes, and anthocyanins, R. damascena flowers have a wide range of pharmacological effects. Five traditional Rosa phytopharmaceuticals are “Golangebin”/ “Golqand (the mixture of petals in honey/sugar), “Jollab”, rose oil, rose water, and rose syrup. In the current study, traditional information about these phytopharmaceuticals was extracted from three medieval manuscripts including “Al-Shamil fi al-Tibb” (13th century AD), “Qarabadin Salehi” (1766), and “Qarabadin Kabir” (1780). Articles on R. damascena petal were found by searching Pubmed, Scopus, and Google Scholar till June 2018. They were mainly related to effectiveness on CNS and GI systems. Numerous studies have been performed to evaluate the efficacy and safety of R. damascena extracts and essential oil, but little has been focused on these phytopharmaceuticals as complementary therapies for the mentioned effects. Comparing recent findings and traditional knowledge of these R. damascena phytopharmaceuticals shows a wide gap between these two viewpoints. Therefore, numerous opportunities are provided to evaluate traditional therapeutic notions about R. damascena phytopharmaceuticals leading to increase for their chances of application.


Main Subjects

[1] Khoshkhui M. Biotechnology of scented roses: a review. Int J Hortic Sci Technol. 2014; 1(1): 1-20.
[2] Widrlechner MP. History and utilization of Rosa damascena. Econ Bot. 1981; 35(1): 42-58.
[3] Pope AU. A survey of Persian art, from prehistoric times to the present. Tehran:  Elmifarhangi Publication, 2008.
[4] Mannschreck A, Angerer E. The scent of roses and beyond: molecular structures, analysis, and practical applications of odorants. J Chem Educ. 2011; 88(11): 1501-1506.
[5] Obon C, Rivera D, Alcaraz F, Attieh L. Beverage and culture. 'zhourat', a multivariate analysis of the globalization of a herbal tea from the Middle East. Appetite. 2014; 79: 1-10.
[6] Pires TCSP, Dias MI, Barros L, Calhelha RC, Alves MJ, Oliveira BPP, Santos-Buelga C, Ferreira ICFR. Edible flowers as sources of phenolic compounds with bioactive potential. Food Res Int. 2018; 105: 580-588.
[7] Nayebi N, Khalili N, Kamalinejad M, Emtiazy M. A systematic review of the efficacy and safety of Rosa damascena Mill. with an overview on its phytopharmacological properties. Complement Ther Med. 2017; 34: 129-140.
[8] Hongratanaworakit T. Relaxing effect of Rose oil in humans. Nat Prod Commun. 2009; 4(2): 291-296.
[9] Heravi MAA. Al-abniyat an-haqayeq al-adviyeh. 2nd ed. Bahmanyar A, Ed. Tehran: Tehran University Press, 1992.
[10] Ghaeni Heravi SM. Qarabadin Salehi. 1st ed. Badr P, Mohagheghzadeh A, Shams Ardakani MR, Ed. Tehran: Choogan Press, 2013.
[11] Barij essence pharmaceutical company. [Accessed 2018]. Available from:
[12] Khan J, Khan R, Qureshi RA. Ethnobotanical study of commonly used weeds of district Bannu, Khyber Pakhtunkhwa (Pakistan). J Med Plants Stud. 2013; 1(2): 1-6.
[13] Bahadur A. Ethnomedicinal study of Merbazghazjahangir Abad, Mardan, Khyber Pukhtoonkhwa. Int J Pharm Res Dev. 2011; 4(1): 129-131.
[14] Sultana Sh, Khan MA, Ahmad M, Zafar M. Indigenous knowledge of folk herbal medicines by the women of district Chakwal, Pakistan. Ethnobot Leaflets.2006; 10(1): 243-253.
[15] Nadaf NY, Patil RS, Zanzurne CH. Effect of addition of gulkand and rose petal powder on chemical composition and organoleptic properties of shrikhand. Rec Res Sci Technol. 2012; 4(10): 52-55.
[16] Pasalar M, Choopani R, Mosaddegh M, Kamalinejad M, Mohagheghzadeh A, Fattahi MR, Ghanizadeh A, Lankarani KB. Efficacy and safety of Jollab to treat functional dyspepsia: a randomized placebo–controlled clinical trial. Explore. 2015; 11(3): 199-207.
[17] Pasalar M, Choopani R, Mosaddegh M, Kamalinejad M, Mohagheghzadeh A, Fattahi MR, Zarshenas MM, Jafari P, Lankarani KB.  Efficacy of Jollab in the treatment of depression in dyspeptic patients: a randomized double-blind controlled trial. J Evid-Based Complement Altern Med. 2015; 20(2): 104-108.
[18] Aghili Khorasani MH. Qarabadin kabir. 1st ed. Beig Babapour Y, Ed. Tehran: Safir Ardehal publication, 2013.
[19] Kashani LMT, Memarzadeh MR, Hatami A, Shirzad M, Ahmadian-Attari MM. Comparison of two different traditional methods of rose oil preparation in terms of physicochemical factors. Trad Integr Med. 2016; 1(2): 69-74.
[20] Agarwal SG, Gupta A, Kapahi BK, Baleshwar, Thappa RK, Suri OP. Chemical composition of rose water volatiles. J Essent Oil Res. 2005; 17(3): 265-267.
[21] Cleveland DEH. The treatment of acne. Can Med Assoc J. 1938; 38(5): 481-483.
[22] Kumar SM, Chandrasekar MJN, Nanjan MJ, Suresh B. Herbal remedies for acne. Nat Prod Rad. 2005; 4(4): 328-334.
[23] Fisk WA, Lev-Tov H, Sivamani RK. Botanical and phytochemical therapy of acne: a systematic review. Phytother Res. 2014; 28(8): 1137-1152.
[24] Dimashqi AHQ. Al-shamil fi sanaat al-tibbia. 1st ed. Tehran: Institute for Study of Medical History, Islamic and Complementary Medicine, 2008. 
[25] Ashrafzadeh F, Rakhshandeh H, Mahmodi E. Rosa damascena oil: an adjunctive therapy for pediatric refractory seizures. Iran J Child Neurol. 2009; 1(4): 13-17.
[26] Niazi M, Hashempur MH, Taghizadeh M, Heydari M, Shariat A. Efficacy of topical rose (Rosa damascena Mill.) oil for migraine headache: a randomized double-blinded placebo-controlled cross-over trial. Complement Ther Med. 2017; 34: 35-41.
[27] Maddahian A, Togha M, Sahranavard S, Riahi SM, Dehghan S, Movahhed M. Effect of “Gol-e-ghand”, a mixture of rose petals and honey, on migraine attacks: a before-after pilot study. Res J Pharmacogn. 2017; 4(4): 33-39.
[28] Atashi N, Bahari SM, Sanatkaran A. The effects of red rose essential oil aromatherapy on athletes’ sleep quality before the competition. J Novel Appl Sci. 2015; 4(7): 814-819.
[29] Keyhanmehr AS, Movahedi M, Sahranavard S, Gachkar L, Hamideh M, Afsharpaiman Sh, Nikfarjad H. The effect of aromatherapy with Rosa damascena essential oil on sleep quality in children. Res J Pharmacogn. 2018; 5(1): 41-46.
[30] Shirazi M, Mohebitabar S, Bioos S, Yekaninejad MS, Rahimi R, Shahpiri Z, Malekshahi F, Nejatbakhsh F. The effect of topical Rosa damascena (rose) oil on pregnancy-related low back pain: a randomized controlled clinical trial. J Evid-Based Complement Altern Med. 2017; 22(1): 120-126.
[31] Bikmoradi A, Harorani M, Roshanaei G, Moradkhani S, Falahinia Gh. The effect of inhalation aromatherapy with damask rose (Rosa damascena) essence on the pain intensity after dressing in patients with burns: a clinical randomized trial. Iran J Nurs Midwifery Res. 2016; 21(3): 247-254.
[32] Marofi M, Sirousfard M, Moeini M, Ghanadi A. Evaluation of the effect of aromatherapy with Rosa damascena Mill. on postoperative pain intensity in hospitalized children in selected hospitals affiliated to Isfahan University of Medical Sciences in 2013: a randomized clinical trial. Iran J Nurs Midwifery Res. 2015; 20(2): 247-254.
[33] Esfandiary E, Karimipour M, Mardani M, Alaei H, Ghannadian M, Kazemi M, Mohammadnejad D, Hosseini N, Esmaeili A. Novel effects of Rosa damascena extract on memory and neurogenesis in a rat model of Alzheimer's disease. J Neurosci Res. 2014; 92(4): 517-530.
[34] Ashrafzadeh F, Rakhshandeh H, Mahmodi E. Rosa damascena oil: An adjunctive therapy for pediatric refractory seizures. Iran J Child Neurol. 2007; 1(4): 13-17.
[35] Rakhshandah H, Hosseini M, Dolati K. Hypnotic effect of Rosa damascena in mice. Iran J Pharm Res. 2004; 3(3): 181-185.
[36] Nyeem MAB, Alam MA, Awal MA, Mostofa M, Uddin SJ, Islam N, Rouf R. CNS depressant effect of the crude ethanolic extract of the flowering tops of Rosa damascena. Iran J Pharmacol Ther. 2006; 5(2): 171-174.
[37] Dolati K, Rakhshandeh H, Shafei MN. Antidepressant-like effect of aqueous extract from Rosa damascena in mice. Avicenna J Phytomed. 2011; 1(2): 91-97.
[38] Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iran J Pharm Res. 2010; 9(2): 163-168.
[39] Boskabady MH, Kiani S, Rakhshandah H. Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanisms. J Ethnopharmacol. 2006; 106(3): 377-382.
[40] Arezoomandan R, Kazerani HR, Behnam-Rasooli M. The laxative and prokinetic effects of Rosa damascena Mill. in rats. Iran J Basic Med Sci. 2011; 14(1): 9-16. 
[41] Abbaszadeh M, Kazerani HR, Kamrani A. Laxative effects of Rosa damascena Mill. in dogs. J Appl Anim Res. 2010; 38(1): 89-92.
[42] Moghaddam MRH, Dolati K, Rakhshandeh H. Cholinergic and histaminergic effects of the aqueous fraction of Rosa damascena extract in guinea pig ileum and rabbit jejunum. Asian J Biol Sci. 2013; 6(1): 67-75.
[43] Shohayeb M, Abdel-Hameed ES, Bazaid SA, Maghrabi I. Antibacterial and antifungal activity of Rosa damascena Mill. essential oil, different extracts of rose petals. Glob J Pharmacol. 2014; 8(1): 1-7.
[44] Yassa N, Masoomi F, Rankouhi SER, Hadjiakhoondi A. Chemical composition and antioxidant activity of the extract and essential oil of Rosa damascena from Iran, population of Guilan. Daru J Pharm Sci. 2009; 17(3): 175-180.
[45] Baydar NG, Baydar H. Phenolic compounds, antiradical activity and antioxidant capacity of oil-bearing rose (Rosa damascena Mill.) extracts. Ind Crops Prod. 2013; 41(1): 375-380.