Burn healing plants in Iranian Traditional Medicine

Document Type : Original paper


1 Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

3 Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


Burns are known as one of the most common forms of injury with devastating consequences. Despite the discovery of several antiseptics, burn wound healing has still remained a challenge to modern medicine. Herbal products seem to possess moderate efficacy with no or less toxicity and are less expensive compared to synthetic drugs. Burn is a well-known disorder in Iranian Traditional Medicine (ITM). Iranian physicians have divided burns into various types based on the cause and recommended treatment for each type. According to ITM references, herbal therapy was the major treatment prescribed by Iranian physicians for burns. In the present study, seven ancient Iranian medical texts were screened for the herbs with burn healing effects along with their applied dosage forms. The medicinal herbs were listed and scored based on the frequency of their repetition. Moreover, the best scientific name that was suitable for each plant as well as surveying modern studies about their biological effects has been carried out. In our investigation eighteen plants with seven topical application categories have been obtained as the most frequent herbs for burn healing in ITM. Modern studies have revealed that these plants have shown some biological activities such as anti-inflammatory, antimicrobial and antioxidant effects which might establish the relationship between the mentioned activities and burn wound healing property. This list can provide a suitable resource for future researches in the field of burn treatment.


[1]  Ezzati A, Bayat M, Taheri S, Mohsenifar Z. Low-level laser therapy with pulsed infrared laser accelerates third -degree burn healing process in rats. J Reh Res Dev. 2009; 46(4): 543-554.
[2]  Upadhyay NK, Kumar R, Siddiqui MS, Gupta A. Mechanism of wound-healing activity of Hippophae rhamnoides L. leaf extract in experimental burns. Evid-Based Complemen Altern Med. 2011; 1-9.
[3]  Khorasani G, Hosseinimehr SJ, Zamani P, Ghasemi M, Ahmadi A. The effect of Saffron (Crocus Sativus) extract for healing of second-degree burn wound in Rats. Keio J Med. 2008; 57(4): 190-195.
[4]  Bahramsoltani R, Farzaei MH, Rahimi R. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res. 2014: 306(7): 601-617.
[5]  Srivastava P, Durgaprasad S. Burn wound healing property of Cocos nucifera: An appraisal. Indian J Pharmacol. 2008; 40(4): 144-146.
[6]  Nasiri E, Hosseinimehr SJ, Azadbakht M, Madani SA. A review of natural products for burn healing based on the Iranian Traditional Medicine. J Mazand Univ Med Sci 2014; 23(110): 263-276.
[7]  Avicenna. Al-qanun fi al -tibb. Beirut: Dar Ehia Al-Tourath Al-Arabi, 2005 (in Arabic).
[8]  Rhazes. Al havi. 1st ed. Afsharypuor S, (Trans.) Tehran: Academy of Medical Sciences, 2005 (in Persian).
[9]  Heravi M. Al-abniah an haghayegh el-adviah 1st ed. Tehran: Tehran University, 1967 (in Persian).
[10]  Ibn al-Baitar A. Al-jāmi li-mufradāt al-adwiyawa al-aghdhiya. 1st ed. Tehran: Iran University of Medical Sciences, Research Institute for Islamic and Complementary Medicine, 2008 (in Arabic).
[11]  Ansari A. Ekhtiarat-e-badiee. 1st ed. Tehran: Razi Pharmaceutical Distribution Company Press, 1992 (in Persian).
[12]  Tonekaboni M. Tohfat-ul-momenin. 1st ed. Tehran: Traditional Medicine and Materia Medica Research Center of Shahid Beheshti University of Medical Sciences and Nashr-e- shahr Press, 2007 (in Persian).
[13]  Aghili Shirazi MH. Makhzan-ul-adviah. 1st ed. Tehran: Iran University of Medical Sciences, Research Institute for Islamic and Complementary Medicine, 2008 (in Persian).
[14]  Afsharypuor S, Shams Ardekani M, Mosaddegh M, Ghannadi A, Mohagheghzadeh A, Badr P. Introduction to Iranian traditional pharmacy and pharmaceutical dosage forms. 1st ed. Tehran: Choogan press and Faculty of Traditional Medicine, Tehran University of Medical sciences, 2013 (in Persian).
[15]  Soltani A. Encyclopedia of traditional medicine, medicinal plants. 1st ed. Tehran: Iran University of Medical Sciences and Health Services, Institute of Medical History, Islamic and Complementary Medicine Research, Medicinal Plants Group, 2004 (in Persian).
[16]  Amin Gh. The most common medicinal plants of Iran. 1st ed. Tehran: Tehran University of Medical Sciences and Health Services, 2005 (In Persian).
[17]  Ghahraman A, Okhovvat AR. Matching the old medicinal plant names with scientific terminology. Vol 1. 1st ed. Tehran: Tehran University, 2004 (in Persian).
[18]  Muhammad HS, Muhammad S. The use of Lawsonia inermis Linn. (henna) in the management of burn wound infections. Afr J biotechnol. 2005; 4(9): 934-937.
[19]  Agarwal P, Alok S, Verma A. An update on Ayurvedic herb Henna (Lawsonia inermis L.): a review. Int J Pharm Sci Res. 2014; 5(2): 330-339.
[20]  Alam G, Singh MP, Singh A. Wound healing potential of some medicinal plants. Int J Pharm Sci Rev Res. 2011; 9(1): 136-145.
[21]  Hsouna AB, Trigui M, Culioli G, Blache Y, Jaoua S. Antioxidant constituents from Lawsonia inermis leaves: isolation, structure elucidation and antioxidative capacity. Food Chem. 2011; 125(1): 193-200.
[22]  Alia B, Bashir A, Tanira M. Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (henna) in rats. Pharmacology. 1995; 51(6): 356-363.
[23]  Prisacaru AI, Andritoiu CV, Andriescu C, Havarneanu EC, Popa M, Motoc AG, Sava A. Evaluation of the wound-healing effect of a novel Hypericum perforatum ointment in skin injury. Rom J Morphol Embryol. 2013; 54(4): 1053-1059.
[24]  Vujanovic S, Vujanovic J. Bioresources in the pharmacotherapy and healing of burns: a mini-review. Burns. 2013; 39(6): 1031-1038.
[25]  Kumar V, Singh PN, Bhattacharya SK. Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L. Indian J Exp Biol. 2001; 39(4): 339-343.
[26]  Zou Y, Lu Y, Wei D. Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro. J Agric Food Chem. 2004; 52(16): 5032-5039.
[27]  Saddiqe Z, Naeem I, Maimoona A. A review of the antibacterial activity of Hypericum perforatum L. J Ethnopharmacol. 2010; 131(3): 511-521.
[28]  Joursaraei S, Moghadamnia A, Rahmani firouzjaei A, Miri S, Omranirad A, Saghebi R, Hashemi S. A comparison on histopathological effects of Myrtle extract and silver sulfadiazine 1% on healing of second degree burn wound in rats. The J Qazvin Univ Med Sci. 2006; 10(1): 5-15.
[29]  Rossi A, Di Paola R, Mazzon E, Genovese T, Caminiti R, Bramanti P, Pergola C, Koeberle A, Werz O, Sautebin L. Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo. J Pharm Exp Ther. 2009; 329(1): 76-86.
[30]  Farzaei MH, Rahimi R, Abbasabadi Z, Abdollahi M. An evidence-based review on medicinal plants used for the treatment of peptic ulcer in traditional Iranian medicine. Int J Pharmacol. 2013; 9(2): 108-124.
[31]  Al-Saimary IE, Bakr SS, Jaffar T, Al-Saimary AE, Salim H, Al-Muosawi R. Effects of some plant extracts and antibiotics on Pseudomonas aeruginosa isolated from various burn cases. Saudi Med J. 2002; 23(7): 802-805.
[32]  Pirbalouti AG, Yousefi M, Nazari H, Karimi I, Koohpayeh A. Evaluation of burn healing properties of Arnebia euchroma and Malva sylvestris. Electron J Biol. 2009; 5(3): 62-66.
[33]  Pirbalouti AG, Azizi S, Koohpayeh A, Hamedi B. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats. Acta Pol Pharm. 2010; 67(5): 511-516.
[34]  Confortia F, Sosa S, Marrelli M, Menichini F, Statti GA, Uzunov D, Tubaro A, Menichini F, Loggia RD. In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants. J Ethnopharmacol. 2008; 116: 144-151.
[35]  Gasparetto JC, Martins CA, Hayash SS, Otuky MF, Pontarolo R. Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine. J Pharm Pharmacol. 2012; 64(2): 172-189.
[36]  Bonjar S. Evaluation of antibacterial properties of some medicinal plants used in Iran. J Ethnopharmacol. 2004; 94(2): 301-305.
[37]  Gürbüz I, Özkan AM, Yesilada E, Kutsal O. Anti-ulcerogenic activity of some plants used in folk medicine of Pinarbasi (Kayseri, Turkey). J Ethnopharmacol. 2005; 101(1): 313-318.
[38]  Güder A, Korkmaz H. Evaluation of in-vitro antioxidant properties of hydroalcoholic solution extracts Urtica dioica L., Malva neglecta Wallr. and their mixture. Iran J Pharm Res. 2012; 11(3): 913-923.
[39]  Vogl S, Picker P, Mihaly-Bison J, Fakhrudin N, Atanasov AG, Heiss EH, Wawrosch C, Reznicek G, Dirsch VM, Saukel J. Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs. J Ethnopharmacol. 2013; 149(3): 750-771.
[40]  Seyyednejad SM, Koochak H, Darabpour E, Motamedi H. A survey on Hibiscus rosa—sinensis, Alcea rosea L. and Malva neglecta Wallr as antibacterial agents. Asian Pac J Trop Med. 2010; 3(5): 351-355.
[41]  Edraki M, Akbarzadeh A, Hosseinzadeh M, Tanideh N, Salehi A, Koohi-Hosseinabadi O. Healing effect of sea buckthorn, olive oil and their mixture on full-thickness burn wounds. Adv Skin Wound Care. 2014; 27(7): 317-323.
[42]  Ghosh PK, Gaba A. Phyto-extracts in wound healing. Int J Pharm Pharm Sci. 2013; 16(5): 760-820.
[43]  Silva S, Gomes L, Leitao F, Coelho A, Boas LV. Phenolic compounds and antioxidant activity of Olea europaea L. fruits and leaves. Food Sci Technol Int. 2006; 12(5): 385-395.
[44]  Süntar İP, Akkol EK, Baykal T. Assessment of anti-inflammatory and antinociceptive activities of Olea europaea L. J Med Food. 2010; 13(2): 352-356.
[45]  Alsaimary IE. Efficacy of some antibacterial agents on Staphylococcus aureus isolated from various burn cases. Int J Med Sci. 2009; 1(4): 110-114.
[46]  Kiran K, Asad M. Wound healing activity of Sesamum indicum L. seed and oil in rats. Indian J Exp Biol. 2008; 46(11): 777-782.
[47]  Suja KP, Jayalekshmy A, Arumughan C. Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH system. J Agric Food Chem. 2004; 52(4): 912-915.
[48]  Harikumar KB, Sung B, Tharakan ST, Pandey MK, Joy B, Guha S, Krishnan S, Aggarwal BB. Sesamin manifests chemopreventive effects through the suppression of NF-κB–regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol Cancer Res. 2010; 8(5): 751-761.
[49]  Rigano D, Conforti F, Formisano C, Menichini F, Senatore F. Comparative free radical scavenging potential and cytotoxicity of different extracts from Iris pseudopumila Tineo flowers and rhizomes. Nat prod res. 2009; 23(1): 17-25.
[50]  Conforti F, Rigano D, Menichini F, Loizzo MR, Senatore F. Protection against neurodegenerative diseases of Iris pseudopumila extracts and their constituents. Fitoterapia. 2009; 80(1): 62-67.
[51]  Bulut C, Altiok E, Bayraktar O, Ülkü S. Antioxidative and antimicrobial screening of 19 commercial essential oils in Turkey. 1st International Medicinal and Aromatic Plants Conference on Culinary Herbs. 2007April 29 - May 4; Antalya, Turkey.
[52]  Eberlin S, Del Carmen Velazquez Pereda M, de Campos Dieamant G, Nogueira C, Werka RM, De Souza Queiroz ML. Effects of a Brazilian herbal compound as a cosmetic eyecare for periorbital hyperchromia (“dark circles”). J Cosmet Dermatol. 2009; 8(2): 127-135.
[53]  Süntar I, Tumen I, Ustün O, Keleş H, Küpeli Akkol E. Appraisal on the wound healing and anti-inflammatory activities of the essential oils obtained from the cones and needles of Pinus species by in vivo and in vitro experimental models. J Ethnopharmacol. 2012; 139(2): 533-540.
[54]  Orhan I, Özçelik B, Şener B. Evaluation of antibacterial, antifungal, antiviral, and antioxidant potentials of some edible oils and their fatty acid profiles. Turk J Biol. 2011; 35(2): 251-258.
[55]  Ninfali P, Bacchiocca M, Antonelli A, Biagiotti E, Di Gioacchino A, Piccoli G, Stocchi V, Brandi G. Characterization and biological activity of the main flavonoids from Swiss Chard (Beta vulgaris subspecies cycla). Phytomedicine. 2007; 14(2): 216-221.
[56]  Jain S, Garg VK, Sharma PK. Anti-inflammatory activity of aqueous extract of Beta vulgaris L. J Basic Clin Pharm. 2011; 2(2): 83-86.
[57]  Koochak H, Seyyednejad SM, Motamedi H. Preliminary study on the antibacterial activity of some medicinal plants of Khuzestan (Iran). Asian Pac J Trop Med. 2010; 3(3): 180-184.
[58]  Lakić NS, Mimica-Dukić NM, Isak JM, Božin BN. Antioxidant properties of Galium verum L. (Rubiaceae) extracts. Cent Eur J Biol. 2010; 5(3): 331-337.
[59]  Prakash B, Mishra PK, Kedia A, Dubey N. Antifungal, antiaflatoxin and antioxidant potential of chemically characterized Boswellia carterii Birdw essential oil and its in vivo practical applicability in preservation of Piper nigrum L. fruits. LWT-Food Sci Technol. 2014; 56(2): 240-247.
[60]  Ammon H. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006; 72(12): 1100-1116.
[61]  Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010; 16(36): 4504-4514.
[62]  Al-kuraishy HM, Al-gareeb AI, Ashoor AW, Al-windy SA. Modifying effects of Boswellia carteri on clarithromycine action: In vitro antibacterial study against common sensitive bacterial strains. Int J Drug Dev Res. 2012; 4(3): 155-162.
[63]  Ashkani-Esfahani S, Imanieh MH, Meshksar A, Khoshneviszadeh M, Noorafshan A, Geramizadeh B, Ebrahimi S, Handjani F, Nadimi E, Jafari SMS. Enhancement of fibroblast proliferation, vascularization and collagen synthesis in the healing process of third-degree burn wounds by topical Arnebia euchroma, a herbal medicine. Galen Med J. 2013; 1(2): 53-59.
[64]  Ashkani-Esfahani S, Imanieh M, Khoshneviszadeh M, Meshksar A, Noorafshan A, Geramizadeh B, Ebrahimi S, Handjani F, Tanideh N. The healing effect of Arnebia euchroma in second degree burn wounds in rat as an animal model. Iran Red Crescent Med J. 2012; 14(2): 70-74.
[65]  Akkol EK, Koca U, Peşin I, Yılmazer D, Toker G, Yeşilada E. Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. J Ethnopharmacol. 2009; 124(1): 137-141.
[66]  Chang MJ, Huang GJ, Ho YL, Lin IH, Huang SS, Chang TN, Chang HY, Chang YS. Study on the antioxidant activities of crude extracts from the roots of Arnebia euchroma and Lithospermum erythrorhizon. Mid Taiwan J Med. 2008; 13: 113-121.
[67]  Kaith B, Kaith N, Chauhan N. Anti-inflammatory effect of Arnebia euchroma root extracts in rats. J Ethnopharmacol. 1996; 55(1): 77-80.
[68]  Kumar GP, Singh SB. Antibacterial and antioxidant activities of ethanol extracts from trans Himalayan medicinal plants. Eur J Appl Sci. 2011; 3(2): 53-57.
[69]  Karayannopoulou M, Tsioli V, Loukopoulos P, Anagnostou TL, Giannakas N, Savvas I, Papazoglou LG, Kaldrymidou E. Evaluation of the effectiveness of an ointment based on alkannins/shikonins on second intention wound healing in the dog. Can J Vet Res. 2011; 75(1): 42-48.
[70]  Papageorgiou V, Assimopoulou A, Ballis A. Alkannins and shikonins: a new class of wound healing agents. Curr Med Chem. 2008; 15(30): 3248-3267.
[71]  Assimopoulou A, Boskou D, Papageorgiou V. Antioxidant activities of alkannin, shikonin and Alkanna tinctoria root extracts in oil substrates. Food Chem. 2004; 87(3): 433-438.
[72]  Assimopoulou A, Papageorgiou V. Radical scavenging activity of Alkanna tinctoria root extracts and their main constituents, hydroxynaphthoquinones. Phytother Res. 2005; 19(2): 141-147.
[73]  Kourounakis AP, Assimopoulou AN, Papageorgiou VP, Gavalas A, Kourounakis PN. Alkannin and Shikonin: effect on free radical processes and on inflammation‐a preliminary pharmacochemical investigation. Archiv Der Pharmazie. 2002; 335(6): 262-266.
[74]  Dhandapani R, Sarkar AK. Antibacterial activity and UV property of shikonin on silk substrate. JTATM. 2007; 5(4): 1-7.
[75]  Elzaawely A, Tawata S. Antioxidant activity of phenolic rich fraction obtained from Convolvulus arvensis L. leaves grown in Egypt. Asian J Crop Sci. 2012; 4(1): 32-40.
[76]  Kaur M, Kalia A. Convolvulus arvensis: A useful weed. Int J Pharm Pharm Sci. 2012; 4(1): 38-40.
[77]  Talib WH, Mahasneh AM. Antimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicine. Molecules. 2010; 15(3): 1811-1824.
[78]  Tyagi PK, Rai VK, Pahria AK, Kumar SS, Singh Y, Sharma M, Goyal M. Preliminary phytochemical screening and evaluation of anti-inflammatory activity of ethanolic extract of leaves of Indigofera tinctoria Linn. J Curr Pharm Res. 2010; 3: 47-50.
[79]  Anusuya N, Manian S. Antioxidant and free radical scavenging potential of different solvent extracts of Indigofera tinctoria L. leaves. Int J Pharm Pharm Sci. 2013; 5(1): 142-147.
[80]  Selvakumar S, Karunakaran C. Antimicrobial efficacy of Senna auriculata, Pongamia glabra and Indigofera tinctoria against pathogenic Microorganisms. Int J Pharm Tech Res. 2010; 2(3): 2054-2059.
[81]  Ravichandran R, Alwarsamy M. Phytochemical screening and in-vitro antibacterial activity of leaf extracts of Indigofera tinctoria Linn. Int J Adv Pharm Res. 2012; 3(4): 872-877.
[82]  Salmah I, Mahmood A, Sidik K. Synergistic effects of alcoholic extract of sweet basil (Ocimum basilicum L.) leaves and honey on cutaneous wound healing in rats. Int J Mol Med Adv Sci. 2005; 1(3): 220-224.
[83]  Abas F, Lajis NH, Israf D, Khozirah S, Umi Kalsom Y. Antioxidant and nitric oxide inhibition activities of selected Malay traditional vegetables. Food Chem. 2006; 95(4): 566-573.
[84]  Selvakkumar C, Gayathri B, Vinaykumar KS, Lakshmi BS, Balakrishnan A. Potential anti-inflammatory properties of crude alcoholic extract of Ocimum basilicum L. in human peripheral blood mononuclear cells. J Health Sci. 2007; 53(4): 500-505.
[85]  Durga KR, Karthikumar S, Jegatheesan K. Isolation of potential antibacterial and antioxidant compounds from Acalypha indica and Ocimum basilicum. J Med Plants Res. 2009; 3(10): 703-706.
[86]  De Sousa MB, Melo OF, De Castro CM, Ximenes EA, Da Silva NH, Da Silva M. Evaluation of the gastric antiulcer, antimicrobial and antioxidant activities of the essential oil from Ocimum minimum Linn. Acta Farm Bonaerense. 2005; 24(3): 331-336.
[87]  Lukmanul Hakkim F, Arivazhagan G, Boopathy R. Antioxidant property of selected Ocimum species and their secondary metabolite content. J Med Plants Res. 2008; 2(9): 250-257.
[88]  Dumitriu B, Olariu L, Nita R, Zglimbea L, Rosoiu N. Vascular anti-inflammatory effects of natural compounds from Aesculus hippocastanum and Hedera helix. Rom Biotech Lett. 2013; 18(1): 7963-7974.
[89]  Rai A. The antiinflammatory and antiarthritic properties of ethanol extract of Hedera helix. Indian J Pharm Sci. 2013; 75(1): 99-102.
[90]  Gülçin İ, Mshvildadze V, Gepdiremen A, Elias R. Antioxidant activity of saponins isolated from ivy: α-hederin, hederasaponin C, hederacolchiside E and hederacolchiside F. Planta Med. 2004; 70(06): 561-563.
[91]  Uddin G, Rauf A, Qaisar M, Latif A, Ali M. Preliminary phytochemical screening and antimicrobial activity of Hedera helix. Middle-East J Sci Res. 2011; 8(1): 198-202.
[92]  Shi G, Wang B, Wu Q, Wang TC, Wang Cl, Sun XH, Zong WT, Yan M, Zhao QC, Chen YF. Evaluation of the wound-healing activity and anti-inflammatory activity of aqueous extracts from Acorus calamus L. Pak J Pharm Sci. 2014; 27: 91-95.
[93]  Raja AE, Vijayalakshmi M, Devalarao G. Acorus calamus Linn.: chemistry and biology. Res J Pharm Technol. 2009; 2(2): 256-261.
[94]  Palani S, Raja S, Praveen R, Devi K, Sivaraj A. Therapeutic efficacy of antihepatotoxic and antioxidant activities of Acorus calamus on acetaminophen-induced toxicity in rat. Int J Integr Biol. 2009; 7(1): 39-44.
[95]  Fazal H, Ahamad N, Khan MA. Physicochemical, phytochemical evaluation and DPPH-scavenging antioxidant potential in medicinal plants used for herbal formulation in Pakistan. Pak J Bot. 2011; 43: 63-67.
[96]  Devi SA, Ganjewala D. Antioxidant activities of methanolic extracts of sweet-flag (Acorus calamus) leaves and rhizomes. J Herbs Spices Med Plants. 2011; 17(1): 1-11.
[97]  Bharathi B, Sundari K, Swamidoss Daniel G. Effect of some medicinal plants on opportunistic bacterial and fungal pathogens associated with HIV. Asian J Pharm Clin Res. 2011; 4(1): 149-154.
[98]  Ghosh S, Samanta A, Mandal NB, Bannerjee S, Chattopadhyay D. Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation. J Ethnopharmacol. 2012; 142: 714-722.
[99]  Li K, Diao Y, Zhang H, Wang S, Zhang Z, Yu B, Huang S, Yang H. Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats. BMC Complemen Altern Med. 2011; 11(86): 1-9.
[100]  Thang PT, Patrick S, Teik LS, Yung CS. Anti-oxidant effects of the extracts from the leaves of Chromolaena odorata on human dermal fibroblasts and epidermal keratinocytes against hydrogen peroxide and hypoxanthine-xanthine oxidase induced damage. Burns. 2001; 27: 319-327.
[101]  Oberyszyn TM. Inflammation and wound healing. Front  Biosci. 2007; 12: 2993-99.
[102]  Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007; 127: 514-525.
[103]  Nonato FR, Santana DG, de Melo FM, dos Santos GGL, Brustolim D, Camargo EA, de Sousa DP, Soares MBP, Villarreal CF. Anti-inflammatory properties of rose oxide. Int Immunopharmacol. 2012; 14(4): 779-784.
[104]  Chandran PK, Kuttan R. Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defense mechanism and granuloma formation during thermal burns. J Clin Biochem Nutr. 2008; 43: 58-64.
[105]  Kahkeshani N, Farahanikia B, Mahdaviani P, Abdolghaffari A, Hassanzadeh G, Abdollahi M, Khanavi M. Antioxidant and burn healing potential of Galium odoratum extracts. Res Pharm Sci. 2013; 8(3): 197-203.
[106]  Annan K, Houghton PJ. Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboretum L., wound-healing plants of Ghana. J Ethnopharmacol. 2008; 119: 141-144.
[107]  Kumari P, Yadav P, Verma PR, Kumar S, Arya A. A review on wound healing properties of Indian medicinal plants. Indian J Fundament App Life Sci. 2013; 3(1): 220-232.
[108]  Nayak BS, Pereira LMP. Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats. BMC Complemen Altern Med. 2006; 6(41): 1-6.