Effect of “Gol-e-ghand”, a mixture of rose petals and honey, on migraine attacks: a before-after pilot study

Document Type : Original paper


1 Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Headache Department, Iranian Center of Neurological Research, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

3 Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Department of Public Health, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran.


Background and objectives: Migraine is the seventh most common cause of disability among all ailments according to the World Health Organization. Despite the availability of some medicines for prevention of migraine, their complications are a cause for concern. Traditional system of medicine and use of medicinal herbs can be beneficial in management of migraine. “Gol-e-ghand” is one of the most commonly prescribed products for the management of headaches in the Iranian traditional medicine. The present study was designed to evaluate the effect of “Ghol-e-ghand” on decreasing the frequency of migraine attacks. Methods: Nineteen migraine patients, who met the eligibility criteria, according to the International Headache Society diagnostic criteria were assigned to the intervention. The study was conducted as a before-after clinical trial and included two phases of drug administration. Propranolol was given during the first phase, while “Ghol-e-ghand” was administered along with propranolol in the second phase. The severity, duration, and frequency of headaches were measured before and after the intervention. Results: The analysis showed that “Ghol-e-ghand” decreased the frequency of migraine (20%, p=0.04), but it was not effective in decreasing the duration and severity of the attacks. Conclusion: “Ghol-e-ghand”can be suggested in migraine patients for reducing frequency of attacks.


[1] Steiner TJ, Birbeck GL, Jensen RH, Katsarava Z, Stovner LJ, Martelletti P. Headache disorders are third cause of disability worldwide. J Headache Pain. 2015; 16(1): 1-3.
[2] Stewart WF, Shechter A, Rasmussen B. Migraine prevalence. A review of population-based studies. Neurology. 1994; 44(64): 17-23.
[3] Waters W, O'connor P. Prevalence of migraine. J Neurol Neurosurg Psychiatry. 1975; 38(6): 613-616.
[4] Launer LJ, Terwindt GM, Ferrari MD. The prevalence and characteristics of migraine in a population-based cohort The GEM Study. Neurology. 1999; 53(3): 537-539.
[5] Ayatollahi SMT, Sahebi L, Borhani Haghighi A. Epidemiologic and clinical characteristics of migraine and tensiontype headaches among hospitals staffs of Shiraz (Iran). Acta Med Iran. 2009; 47(2): 115-120.
[6] Steiner TJ. Headache in the world: public health and research priorities. Expert Rev Pharmacoecon Outcomes Res. 2013; 13(1): 51-57.
[7] World Health Organization. Atlas of headache disorders and resources in the world 2011. Geneva: World Health Organisation, 2011.
[8] Pal SK, Shukla Y. Herbal medicine: current status and the future. Asian Pac J Cancer Prev. 2003; 4(4): 281-288.
[9] Borhani Haghighi A, Motazedian S, Rezaii R, Mohammadi F, Salarian L, Pourmokhtari M, Khodaei S, Vossoughi M, Miri R. Cutaneous application of menthol 10% solution as an abortive treatment of migraine without aura: a randomised, double‐blind, placebo‐controlled, crossed‐over study. Int J Clin Pract. 2010; 64(4): 451-456.
[10] Wang L, Zhang J, Hong Y, Feng Y, Chen M, Wang Y. Phytochemical and pharmacological review of da chuanxiong formula: a famous herb pair composed of chuanxiong rhizoma and gastrodiae rhizoma for headache. Evid Based Complement Altern Med. 2013; Article ID 425369.
[11] Kamali SH, Khalaj AR, Hasani-Ranjbar S, Esfehani MM, Kamalinejad M, Soheil O, Kamali SA. Efficacy of ‘Itrifal Saghir’, a combination of three medicinal plants in the treatment of obesity; a randomized controlled trial. Daru J Pharm Sci. 2012; Article ID 3559014.
[12]  Zargaran A, Zarshenas MM, Mehdizadeh A, Mohagheghzadeh A. Management of tremor in medieval Persia. J Hist Neurosci. 2013; 22(1): 53-61.
[13] Jorjani S. Zakhire-ye-Kharazmshahi. Tehran: Iranian Medical Science Culture Publication, 2003.
[14] Avicenna. The Canon of medicine. Tehran: Soroush press, 1997.
[15] Arzani MA. Tebb-e-Akbari. QOM: Jalaleddin, 2008.
[16] Zaidi SF, Muhammad JS, Shahryar S, Usmanghani K, Gilani AH, Jafri W, Sugiyama T. Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells. J Ethnopharmacol. 2012; 141(1): 403-410.
[17] Sadraei H, Asghari G, Emami S. Inhibitory effect of Rosa damascena Mill. flower essential oil, geraniol and citronellol on rat ileum contraction. Res Pharm Sci. 2013; 8(1): 17-23.
[18] Joukar S, Askarzadeh M, Shahouzehi B, Najafipour H, Fathpour H. Assessment of safety and therapeutic efficacy of Rosa damascena L. and Quercus infectoria on cardiovascular performance of normal and hyperlipidemic rabbits: physiologically based approach. J Toxicol. 2013; Article ID 769143.
[19] Loghmani-Khouzani H, Sabzi Fini O, Safari J. Essential oil composition of Rosa damascena Mill. cultivated in central Iran. Sci Iran. 2007; 14(4): 316-319.
[20] Zargaran A, Borhani-Haghighi A, Faridi P, Daneshamouz S, Kordafshari G, Mohagheghzadeh A. Potential effect and mechanism of action of topical chamomile (Matricaria chammomila L.) oil on migraine headache: a medical hypothesis. Med Hypotheses. 2014; 83(5): 566-569.
[21] Moein S, Moein M, Khoshnoud MJ, Kalanteri T. In vitro antioxidant properties evaluation of 10 Iranian medicinal plants by different methods. Red Crescent Med J. 2012; 14(12): 771-775.
[22] Jazayeri SB, Amanlou A, Ghanadian N, Pasalar P, Amanlou M. A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine. Daru J Pharm Sci. 2014; Article ID 3896674.
[23] Yassa N, Masoomi F, Rankouhi SR, Hadjiakhoondi A. Chemical composition and antioxidant activity of the extract and essential oil of Rosa damascena from Iran, population of Guilan. Daru J Pharm Sci. 2015; 17(3): 175-180.
[24] Aghili Khorasani MH. Makhzan-al-advia. Tehran: Rahe kamal, 2009.
[25] Aghili Khorasani MH. Kholase-ol-hekma. Qom: Ismailian, 2006.
[26] Rhazes. Al havi [liber continent]. Tehran: Academy of medical sciences publication, 2005.
[27] Zarshenas MM, Petramfar P, Firoozabadi A, Moein MR, Mohagheghzadeh A. Types of headache and those remedies in traditional persian medicine. Pharmacogn Rev. 2013; 7(13): 17-26.
[28] Kasmaei HD, Ghorbanifar Z, Zayeri F, Minaei B, Kamali SH, Rezaeizadeh H, Amin G, Ghobadi A, Mirzaei Z. Effects of Coriandrum sativum syrup on migraine: a randomized, triple-blind, placebo-controlled trial. Red Crescent Med J. 2016; Aticle ID 4752800.
[29] Noghani MT, Rezaeizadeh H, Fazljoo SMB, Yousefifard M, Keshavarz M. Gastrointestinal headache; a narrative review. Emerg. 2015; 4(4): 171-183.
[30] Gorji A. Pharmacological treatment of headache using traditional Persian medicine. Trends Pharmacol Sci. 2003; 24(7): 331-334.
[31] Abokrysha N. Ibn Sina (Avicenna) on pathogenesis of migraine compared with the recent theories. Headache. 2009; 49(6): 923-927.
[32] Lucas C, Romatet S, Mekiès C, Allaf B, Lantéri‐Minet M. Stability, responsiveness, and reproducibility of a visual analog scale for treatment satisfaction in migraine. Headache. 2012; 52(6): 1005-1018.
[33] Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascena. Iran J Basic Med Sci. 2011; 14(4): 295-307.
[34] Schieber A, Mihalev K, Berardini N, Mollov P, Carle R. Flavonol glycosides from distilled petals of Rosa damascena Mill. ‎Z Naturforsch C Biosci. 2005; 60(5-6): 379-384.
[35] Zargaran A, Borhani-Haghighi A, Faridi P, Daneshamouz S, Mohagheghzadeh A. A review on the management of migraine in the Avicenna’s Canon of Medicine. Neurol Sci. 2016; 37(3): 471-478.
[36] Benemei S, De Cesaris F, Fusi C, Rossi E, Lupi C, Geppetti P. TRPA1 and other TRP channels in migraine. J Headache Pain. 2013; Article ID 3844362.
[37] Bernstein C, Burstein R. Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol. 2012; 8(2): 89-99.
[38] Rakhshandah H, Hosseini M, Dolati K. Hypnotic effect of Rosa damascena in mice. Iran J Pharm Res. 2010; 3(3): 181-185.
[39] Jafarpour M, Yousefi G, Hamedi A, Shariat A, Salehi A, Heydari M. Effect of a traditional syrup from Citrus medica L. fruit juice on migraine headache: A randomized double blind placebo controlled clinical trial. J Ethnopharmacol. 2016; 179: 170-176.
[40] Gharabaghi PM, Tabatabei F, Fard SA, Sayyah-Melli M, Del Azar EOA, Khoei SA, Gharabaghi MM, Ghojazadeh M, Mashrabi O. Evaluation of the effect of preemptive administration of Rosa damascena extract on post-operative pain in elective cesarean sections. Iran J Nurs Midwifery Res. 2011; 5(16): 1950-1955.
[41] Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iran J Pharm Res. 2010; 9(2): 163-168.
[42] Kim YJ, Lee MS, Yang YS, Hur MH. Self-aromatherapy massage of the abdomen for the reduction of menstrual pain and anxiety during menstruation in nurses: a placebo-controlled clinical trial. Eur J Integr Med. 2011; 3(3): 165-168.
[43] Holroyd KA, Penzien DB, Cordingley GE. Propranolol in the management of recurrent migraine: a meta‐analytic review. Headache. 1991; 31(5): 333-340.