Cuscuta chinensis Antidepressant-Like Effect, the Role of 5-HT and the Impact on Behavioral Response in Mice

Document Type : Short communication

Authors

1 Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

10.22127/rjp.2022.338343.1885

Abstract

Background and objectives: Depression is a chronic mental disorder that influences people’s lives and functionality.  The available medications do not give full guaranty of effectiveness and are not devoid of unwanted side effects.  Cuscuta chinensis has been recommended for the treatment of depression in traditional medicine. In this study, the antidepressant-like activity of C. chinensis has been evaluated by using forced swimming test (FST) in mice. Methods: Cuscuta chinensis extract was provided by boiling in water. The antidepressant effect was evaluated by forced swimming test (FST) in mice with daily gavage of 270, 360 and 430 mg/kg of the treatments for four weeks. The immobility time and behavioral activity and also the blood levels of 5-HT and norepinephrine were measured. Results: The FST confirmed antidepressant effect of the extract with decreased time of immobility and increased swimming time alongside increase in serum 5-HT in all groups (p<0.01compared to the control) except for the extract at the dose of 270 mg/kg (MA270).  This effect was not statistically significant with fluoxetine group. Conclusion: Cuscuta chinensis demonstrated antidepressant effects in mice model which is a confirmation for its traditional use in depression.

Keywords


  • Mao QQ, Ip SP, Xian YF, Hu Z, Che CT. Anti-depressant-like effect of peony: a mini-review. Pharm Biol. 2012; 50(1): 72–77.
  • Park SW, Kim YK, Lee JG, Kim SH, Kim JM, Yoon JS, Park YK, Lee YK, Kim YH. Anti-depressant-like effects of the traditional Chinese medicine kami-shoyo-san in rats. Psychiatry Clin Neurosci. 2007; 61(4): 401–406.
  • Peng FZ, Fan J, Ge TT, Liu QQ, Li BJ. Rapid anti-depressant-like effects of ketamine and other candidates: molecular and cellular mechanisms. Cell Prolif. 2020; 53(5): 1–13.
  • Kahkeshani N, Hadjiakhoondi A, Navidpour L, Akbarzadeh T, Safavi M, Karimpour-Razkenari E, Khanavi M. Chemodiversity of Nepeta menthoides & Bohse. essential oil from Iran and antimicrobial, acetylcholinesterase inhibitory and cytotoxic properties of 1,8-cineole chemotype. Nat Prod Res. 2018; 17(4): 544–552.
  • Fahimi S, Mortazavi SA, Abdollahi M, Hajimehdipoor H. Formulation of a traditionally used polyherbal product for burn healing and HPTLC fingerprinting of its phenolic contents. Iran J Pharm Res. 2016; 15(1): 95–105.
  • Can A, Dao DT, Arad M, Terrillion CE, Piantadosi SC, Gould TD. The mouse forced swim test. J Vis Exp. 2012; 59: 1–5.
  • Gupta M, Mazumder UK, Pal D, Bhattacharya S, Chakrabarty S. Studies on brain biogenic amines in methanolic extract of Cuscuta reflexa and Corchorus olitorius Linn. seed treated mice. Acta Pol Pharm. 2003; 60(3): 207–210.
  • Ahmad A, Tandon S, Dang Xuan T, Nooreen Z. A review on phytoconstituents and biological activities of Cuscuta Biomed Pharmacother. 2017; 92: 772–795.
  • Pan S, Wang X, Duan W, Yu Z, Zhang L, Liu W. Preparative isolation and purification of flavonoids from Cuscuta chinensis by high-speed counter current chromatography. J Liq Chromatogr Relat Technol. 2013; 37(15): 2162–2171.
  • Li WL, Zhang Y, Bai J, Xiang Z, Ding JX, Ji YB. Identification of chemical constituents in Cuscuta chinensis using HPLC-ESI/ Q-TOF MS/MS. Bio Technol Indian J. 2013; 8(4): 563–567.
  • Kwon YS, Chang BS, Kim CM. Antioxidative constituents from the seeds of Cuscuta chinensis. Nat Prod Sci. 2000; 6(3): 135–138.
  • Hritcu L, Ionita R, Postu PA, Gupta GK, Turkez H, Lima TC, Carvalho C, de Sousa DP. Antidepressant flavonoids and their relationship with oxidative stress. Oxid Med Cell Longev. 2017; Article ID 5762172.
  • Pannu A, Sharma PC, Thakur VK, Goyal RK. Emerging role of flavonoids as the treatment of depression. Biomolecules. 2021; 11(2): 1–49.
  • Khan H, Perviz S, Sureda A, Nabavi SM, Tejada S. Current standing of plant derived flavonoids as an antidepressant. Food Chem Toxicol. 2018; 119: 176–188.

Detke MJ, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl). 1995; 121(1): 66–72.