Document Type : Original paper
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Traditional Medicine, School of Traditional Medicine Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background and objectives: Anti-proliferative activity of carnosol from Rosemary on malignancies has revealed its potential for cancer therapeutic purposes. Molecular studies such as proteomics could open a new insight in underling mechanisms of anticancer processes of carnosol treatment through analysis of the most relevant modulated proteins in cancer. Methods: Protein-protein interaction (PPI) network analysis of adult T-cell leukemia/lymphoma (ATL) treated with carnosol proteome was conducted. Cyroscape and its plug-ins explored the PPI network construction and its features including centrality and gene ontology. Results: Among 22 differentially expressed proteins (DEPs), 21 individuals were recognized by the STRING database. The queried DEPs and the added first neighbors formed a scale-free network. GAPDH, TPI1, ENO1, and PGK1 were identified as the hub-bottlenecks of the PPI network of carnosol-treated ATL. Conclusion: ALDOA, PFKFB3, PKM2, and LDHA and related metabolic processes are targets of anticancer compounds of rosemary extract; however, more investigation is suggested.