Document Type : Review
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Celiac disease, also known as gluten intolerance, is an autoimmune digestive disorder in genetically susceptible individuals. Currently, a totally gluten free diet is considered as the only treatment for celiac disease, which means cutting out foods containing gluten protein from the diet completely. Strict adherence to this regimen can be challenging as several processed foods contain hidden gluten, added as flavor enhancer or texture modifier. In addition, the high cost and unavailability of gluten-free foods have led to patient's dissatisfaction. Moreover, there are celiac disease patients who have persistent symptoms despite dietary compliance. Emerging research have focused on discovering alternative non-dietary treatments for this disorder. There are herbal medicines and other natural resources with anti-inflammatory activity and valuable therapeutic effects in preventing or treating inflammatory diseases. As these are effective and affordable, several studies have focused on treating different diseases using these agents. However, there are few studies evaluating the effects and potential role of naturally derived compounds in celiac disease treatment. In this review, we gathered current information in this regard; hoping our article can serve as catalysts for researchers to pay more attention to natural therapies for celiac disease.