Assessment of Molecular Mechanism of Saffron Anti-Stress Property

Document Type : Original paper


1 Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

2 Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

6 Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


Background and objectives: There are several documents about protective properties of saffron against stress conditions which refer to the effect of saffron on gene expression pattern of the treated samples.The aim of the present study was determination of the main regulated proteins by saffron extract. Methods: Twenty differentially expressed proteins from a published research were investigated via network analysis and assessed to determine the crucial regulated individuals by Cetoscape software. The network was analyzed by network analyzer application of Cytoscape software, and the central nodes were identified. Results: Twenty queried proteins were included in a network with 9005 nodes and 11446 edges. Analysis of the network revealed that VCP, SOD1, GRP78 (HSPA5), GRP75 (HSPA9), PRDX1, PHB, COMT, and ATP5H are the central proteins which are regulated by saffron extract. Conclusion: Based on the regulated proteins, regulation of mithoconderia and endoplasmic reticulum was identified as the main target of saffron in stress management.


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