Comparative Effects of Mouthwash Containing Trachypermum ammi Oil with Chlorhexidine on Dental Plaque Induced Gingivitis

Document Type : Original paper


1 School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran. Department of Periodontology, International Campus, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

2 Department of Periodontology, International Campus, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

3 Department of Health Science Educational Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

4 Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


Background and objectives: The primary etiology for gingivitis is dental plaque resulting in gum inflammation. Beside mechanical procedures, chemical agents in mouthwash can help in removal of plaques. Oil of Trachyspermum ammi rich in thymol may provide beneficial effect in control of gingivitis; therefore, the present study aimed to compare the effect of mouthwash containing the oil with chlorhexidine to control dental plaque and inflammation of gingivae. Methods: Essential oil of the plant was analyzed using GC-MS and amount of thymol was assayed by GC method. Herbal mouthwash was prepared and applied in an open-label non-randomized study, adult female and male suffering of gingivitis (N=30) entered in two groups after oral prophylaxis. Examining for plaque index (PI), bleeding index (BI), and modified gingival index (MGI) were conducted after two weeks administration of the herbal mouthwash. Results: The herbal mouthwash was stable for two months with no physical change and microbial contamination (0.05). Conclusion: The effect of T. ammi oil in control of inflammation was comparable with chlorhexidine, while chlorhexidine reduced risks of PI, BI, and MGI higher than those receiving the herbal mouthwash.


Main Subjects

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