- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Bioassay Guided Fractionation of Allium austroiranicum by Cytotoxic Effects against Ovary and Cervical Cancer Cell Lines169691910.22127/rjp.2019.190642.1506ENMasoud Sadeghi DinaniDepartment of Pharmacognosy, Faculty of Pharmacy, Isfahan University of Medical Sciences,Isfahan, Iran0000-0001-5565-3875Narges Zakeri TehraniDepartment of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.Fatemeh Shafiee*Department of Pharmaceutical Biotechnology, Isfahan University of Medical Sciences, Isfahan, Iran.0000-0001-6484-1931Journal Article20190618<strong>Background and objectives:</strong> Cancer is a major health problem in the world. The aim of this study was to extract the flowers of <em>Allium austroiranicum </em>used by Iranian people as a condiment or for its medicinal effects followed by bioassay guided fractionation of the extracts and fractions, using anti-proliferative effects against ovarian and cervical cancer cells. <strong>Methods: </strong>The air-dried flowers of <em>Allium austroiranicum</em> were extracted in a four-step extraction method, resulting hexan, chloroform, chloroform: methanol (9: 1), butanol and aqueous extracts. Anti-proliferative effects of the extracts were evaluated by MTT assay against OVCAR-3, HeLa, and HUVEC cell lines. The most potent cytotoxic extract was then subjected to fractionation by MPLC method on a RP-18 silicagel column. Finally, the cytotoxic effects of resulted fractions were analyzed again and the most potent cytotoxic fraction and its IC<sub>50</sub> were determined. <strong>Results: </strong>Statistical analysis showed thatbutanol extract of <em>A. austroiranicum</em> showed the most potent cytotoxic effects against OVCAR-3, HeLa and HUVEC cell lines with IC<sub>50</sub> values of 38±2, 56±1.4, and 60±3.5 µg/mL, respectively. On the other hand, for 7 fractions resulting from fractionation of the butanol extract, MTT assay results showed that 6<sup>th</sup> fraction (F) was the most cytotoxic fraction with IC<sub>50</sub> of 2.7±0.26 and 7.5±0.5 µg/mL for OVCAR-3 and HeLa cancer cell lines, respectively. Primary evaluation of the fraction by TLC and NMR analysis suggested the steroidal saponins as the main constituents. <strong>Conclusion:</strong> <em>Allium austroiranicum</em> showed significant cytotoxic effects against ovarian cancer cell line especiallyfractions assumed to contain steroidal saponins. The fraction constituents have the potential of being strong cytotoxic agents and the isolation and identification of compounds are suggested.https://www.rjpharmacognosy.ir/article_96919_59a6e7534e50d51778a1ecc1c485666f.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Pharmacognostic Characteristics and Mutagenic Studies of Alstonia boonei De Wild7159692910.22127/rjp.2019.204629.1526ENEmelia Oppong Bekoe*Department of Pharmacognosy & Herbal Medicine, School of Pharmacy, University of Ghana, Ghana.0000-0002-9875-2387Kirk DodooDepartment of Pharmacognosy & Herbal Medicine, School of Pharmacy, University of Ghana, Ghana.Cindy KitcherDepartment of Pharmacognosy & Herbal Medicine, School of Pharmacy, University of Ghana, Ghana.Andrew GordonDepartment of Science and Laboratory Technology, Accra Technical University, Ghana.Samuel Frimpong-MansoDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of Ghana, Ghana.Gladys SchwingerInstitute of Environment and Sanitation Studies, School of Biological Sciences, University of Ghana, Ghana.Journal Article20191014<strong>Background and objectives: </strong>The bark of<em> Alstonia boonei</em>, known as stool wood, is sold in large quantities on the Ghanaian market. It is used for the treatment of numerous ailments including snake bites, worm infestation, malaria and rheumatic pains. For safety reasons, it is necessary to control the raw materials by setting simple but relevant parameters to ensure identity, purity and quality which have been the aim of the present study to authenticate the plant materials. <strong>Methods: </strong>The macroscopic, microscopic, physico-chemical, phytochemical, UV-visible, fluorescence, HPLC and elemental characteristics were evaluated. Mutagenicity was also investigated with the Ames test. <strong>Results: </strong>The leaf characteristics can be employed to preliminary confirm the identity of the plant.The greyish-green outer bark and inner cream bark is rough, short and splintery with a bitter taste.The powdered stem bark showed microscopic prismatic calcium oxalate crystals, scalariform xylem vessels and lignified brachysclereids. Phytochemicals present were alkaloids, saponins, tannins, flavonoids, glycosides and terpenes. The bark fluoresced reddish-brown in 50 %v/v H<sub>2</sub>SO<sub>4</sub> under UV light of λ 254 nm and contained traces of Cd, Fe, Zn and As, which were within recommended limits. HPLC fingerprint showed peaks at 254 nm, and UV analysis in various solvents showed spectral shifts on ionization. <em>A. boonei</em> demonstrated mutagenicity in Ames test. <strong>Conclusion: </strong>The characteristic macroscopic, microscopic, physico-chemical and chemical parameters evaluated for the plant sample can be used in rapid identification, authentication and establishment of the quality of raw materials. This will improve the quality and hence efficacy. The mutagenicity suggests the need for further safety evaluation.https://www.rjpharmacognosy.ir/article_96929_02e861ea19c528a253f9b145199c689f.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Hydatid Cyst Killing Mechanism of Ziziphora tenuior by Inducing Apoptosis via Mitochondrial Intrinsic Pathway17229692110.22127/rjp.2019.192139.1510ENMojtaba ShahnaziCellular & Molecular Research Institute, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Parasitology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.0000-0002-6147-3739Abbas Azadmehr*Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.0000-0002-7698-9885Hamidreza AghaeiCellular & Molecular Research Institute, Qazvin University of Medical Sciences, Qazvin, Iran.Reza HajiaghaeeMedicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.Morteza OladnabidozinGorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.Reza NorianDepartment of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.Mehrzad SaraeiCellular & Molecular Research Institute, Qazvin University of Medical Sciences, Qazvin, Iran.Mahmood AlipourDepartment of Social Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.Journal Article20190702<strong>Background and objectives:</strong> <em>Ziziphora tenuior</em> is considered as an appropriate protoscolicidal agent yet the mechanism of such effect is not known so far. The aim of this study was to evaluate the apoptotic effect of <em>Z. tenuior</em> extract on protoscolices of hydatid cyst.<strong> Methods:</strong> Protoscolices were collected aseptically and the Bradford test was employed to determine the number required for the experiments. Various concentrations of <em>Z. tenuior </em>extract (5, 50, and 100 mg/mL) was incubated with hydatid cyst protoscolices at 37 <sup>o</sup>C and 5% Co<sub>2</sub> for 4 h. The apoptotic effect of <em>Z. tenuior</em> extract on hydatid cyst protoscolices and the evaluation of caspases 3, 8, and 9 activities were ditermined using ELISA-based commercial diagnostic kits. <strong>Results:</strong> In the present study, 50 and 100 mg/mL of <em>Z. tenuior</em> extract produced apoptosis in the protoscolices of hydatid cyst significantly (p<0.05). Also, the activity of caspase 3 at 50 and 100 mg/mL significantly increased by 29.99% and 36.01%, respectively (p<0.05). Similarly, caspase 9 also demonstrated a significant increased activity up to 15.23%, and 45.31% at the same concentrations used for caspase 3, respectively (p<0.05). <strong>Conclusion:</strong> Our findings in this study indicated that, <em>Z. tenuior</em> extract can induce apoptotic cell death on hydatid cyst protoscolices by increasing the activity of caspases 3 and 9 via the internal apoptotic pathway.https://www.rjpharmacognosy.ir/article_96921_500f20cff985497c023a73f9938d4680.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Evaluation of Antioxidant, Antibacterial and Cytotoxic Activity of Methanol Extract from Leaves and Fruits of Iranian Squirting Cucumber (Ecballium elaterium (L.) A. Rich)23299693010.22127/rjp.2019.190800.1509ENMasoud HamidiFood and Drug Research Center, Vice-Chancellery of Food and Drug, Guilan University of Medical Sciences, Rasht, Iran.0000-0003-3847-4247Saeed GhasemiDepartment of Medicinal Chemistry, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.0000-0003-2007-2063Bahman Bavafa BighdilouDepartment of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, , Iran.Diba Eghbali KoohiDepartment of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, , Iran.Fatemeh Yousefbeyk*Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, , Iran.0000-0002-2793-6445Journal Article20190622<strong>Background and objectives</strong>: <em>Ecballium elaterium</em> (L.) A. Rich (squirting cucumber) has been used traditionally as a remedy for different disorders such as fever, sinusitis, and rheumatic disease. In the present study, antibacterial, antioxidant, and cytotoxic activities of leaves and fruits were evaluated. Also, total flavonoid and phenolic contents were measured were measured. <strong>Methods: </strong>The fruits and leaves of <em>E. elaterium</em> were extracted by percolation method with methanol. The antioxidant activity was assessed by 2, 2'-diphenyl-1-picrylhydrazyl (DPPH) methods. Then, the total phenolics and flavonoids contents were measured. The cytotoxicity was tested against three cancerous cell lines (MCF-7, MDA-MB-468 and MKN-45) and a normal cell line (HDF). Antibacterial activity was investigated against <em>Staphylococcus aureus</em>, <em>Enterococcus faecalis</em>, <em>Pseudomonas aeruginosa,</em> and <em>Escherichia coli</em>. <strong>Results:</strong> The total phenolics content of leaves and fruits were 39.97 and 30.90 mg gallic acid equivalents/g of dry extract, respectively. Also, the total flavonoids content in leaf extract was 49.17 mg quercetin as equivalents/g of dry extract while flavonoids were not detected in the fruit extract. In the DPPH assay, the IC<sub>50</sub> values were 1.15 and 1.18 mg/mL for leaves and fruits, respectively.The fruit extract showed the most considerable antibacterial activity (MIC 37.5 mg/mL) against <em>P. aeruginosa</em>. Both extracts indicated cytotoxicity on MDA-MB-468 cells (IC<sub>50</sub> 264 and 50 µg/mL, respectively). <strong>Conclusion</strong>: The antioxidant, antibacterial, and cytotoxicity of extracts may be due to some secondary metabolites like phenolic compounds and flavonoids. This study suggests that this plant could be considered for further investigations as a natural source of biological compounds.https://www.rjpharmacognosy.ir/article_96930_484e78c45a95d80085ae13536bf59118.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101A Comparative Evaluation of Nephroprotective Property of Urtica dioica L. Aqueous Extract and Glibenclamide in Diabetic Mice31409694810.22127/rjp.2018.121067.1372ENMohammad Mahdi ZangenehBiotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran. Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.0000-0002-8090-2244Ghobad MohammadiPharmaceutical Sciences Research Center, Health Institute, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.0000-0002-6202-9840Saman SalmaniDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.Payam Razeghi TehraniDepartment of Basic Sciences, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran.Khodabakhsh RashidiResearch Center of Oils and Fats (RCOF), Kermanshah University of Medical Sciences, Kermanshah, Iran.Akram Zangeneh*Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran. Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.0000-0001-8129-8432Journal Article20190301<strong>Background and objectives:</strong>Diabetes is the most common metabolic disorder with severe effects on quality of life. Decreasing serum glucose levels and normalization of kidney parameters is of great clinical importance for treating diabetes. <em>Urtica dioica</em> L. has been used in as anti-inflammatory, antioxidant, anti-fungal, and antibacterial agent. To our knowledge, there are little evidences about the anti-diabetic and nephroprotective actions of <em>U. dioica</em> L. The present study was carried out to assess the anti-diabetic and nephroprotective activities of <em>U. dioica </em>aqueous extract (UDAE) in streptozotocin (STZ) induced diabetic mice for 20 days. <strong>Methods:</strong> Male mice were divided into six groups: normal control, untreated diabetic, diabetic mice receiving 30, 90 and 270 mg/kg of plant extract (groups UDAE30, UDAE90 and UDAE270, respectively) or 30 mg/kg glibenclamide. At 20<sup>th</sup> day, the mice killed, dissected, then blood and kidney samples were collected for biochemical and histological parameters analysis. <strong>Results: </strong>Biochemically, UDAE at all doses and glibenclamide could significantly (p<em>≤</em>0.05) reduce the raised levels of blood glucose, urea and creatinine when compared to the untreated group. Histologically, differentdoses of UDAE (especially UDAE270) and glibenclamide could significantly (p<em>≤</em>0.05) decrease the volume and length of the renal structures as compared to the untreated group. <strong>Conclusion: </strong>These results indicated thatUDAE could improve diabetic related metabolic derangement such as hyperglycemia and elevated kidney markers.<br /> <br /> <strong> </strong>https://www.rjpharmacognosy.ir/article_96948_f93f1d132459d04c962e64f4fa4f61fa.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Anti-parasitic Activity of Some Medicinal Plants Essential Oils on Giardia lamblia and Entamoeba histolytica, In Vitro41479694410.22127/rjp.2019.168142.1462ENMohammad AzadbakhtDepartment of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.0000-0002-2451-4968Aroona Chabra*Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.0000-0002-2432-0362Ali Saeedi AkbarabadiDepartment of Pharmacognosy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Mohammad Hossein MotazedianDepartment of Parasitology and Mycology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Taha MonadiStudent Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.0000-0003-3526-4789Fatemeh AkbariStudent Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.Journal Article20190116<strong>Background and objectives:</strong> Giardiasis and amoebiasis are two common diseases in human societies which make increasing problems for the health managing systems. In the present study, the antiparasitic activity of <em>Allium sativum</em>, <em>Artemisia sieberi</em>, <em>Zatraria multiflora</em>, <em>Chenopodium botrys</em> and <em>Eucalyptus globulus</em> essential oils on <em>Giardia lamblia</em> cysts and <em>Entamoeba histolytica</em> trophozoites were investigated in vitro. <strong>Methods: </strong><em>Giardia lamblia</em> cysts and <em>E. histolytica</em> trophozoites were isolated from infected sample stools. The parasites were treated by four concentrations (0.2, 0.1, 0.01 and 0.001 µg/mL) of essential oils, separately for 30 min at 37 °C.<strong> Results: </strong>Theessential oils at the concentration of 0.1 and 0.2 µg/mL indicated appreciate parasiticidal effect (p <0.05). <em>Eucalyptus globulus</em> had maximum efficacy on both <em>G. lamblia</em> and <em>E. histolytica</em> with mortality rates of 79.7% and 87.6% within 30 min. <strong>Conclusion:</strong> All essential oils showed potent anti-giardiasis and anti-amoebiasis activity. Also, <em>E. globulus</em> with the highest efficiency could be considered as anti-protozoa medication to use an adjunct or primary therapy.https://www.rjpharmacognosy.ir/article_96944_918564ca88cfeaef889b63140c2b1418.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Comparing the Effect of Nigella sativa oil Soft Gel and Placebo on Oligomenorrhea, Amenorrhea and Laboratory Characteristics in Patients with Polycystic Ovarian Syndrome, a Randomized Clinical Trial49599928910.22127/rjp.2019.206178.1530ENSeyedeh Atieh NaeimiDepartment of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0003-4448-4695Mojgan Tansaz*Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0002-9348-4635Homa HajimehdipoorTraditional Medicine and Materia Medica Research Center and Department of Traditional pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0002-2739-3399Sojdeh SaberMedical clinic of Guilan University, Guilan University of Medical Sciences, Rasht, Iran.Journal Article20191023<strong>Background and objectives:</strong> Oligo-amenorrhea is one of the most common symptoms in poly cystic ovarian syndrome (PCOS) patients and<em> Nigella sativa</em> is a medicinal plant used in Iranian traditional medicine for the treatment of oligo-amenorrhea. The aim of this study was to evaluate the effect of <em>N. sativa </em>oil on oligo-amenorrhea in patients with PCOS. <strong>Methods:</strong> This study was a double-blinded placebo-controlled clinical trial conducted on 84 PCOS patients with oligo-amenorrhea. Patients were randomly assigned to intervention and placebo group. They used two soft gel capsules of <em>N. sativa</em> oil (500 mg, each capsule) or placebo at night for sixteen weeks. Four indices were used to assess menstruation; the interval between menstruations, duration of menstruation, the occurrence of menstruation and the severity of bleeding. The two groups were compared using analysis of covariance. <strong>Result:</strong> Fifty five patients completed the study (32 patients in <em>N. sativa</em> group and 23 patients in placebo group). The menstrual interval after the study in the intervention group (45 days, 95% CI) was significantly lower than the control group (86 days). The frequency of menstrual cycle in the intervention group (0.79) was significantly higher than the placebo group (0.48). No serious complication was reported in this clinical trial. <strong>Conclusion:</strong> findings suggest that <em>N. sativa</em> is an alternative treatment and could be useful for menstrual irregularities in women with PCOS. Further studies are recommended to find the exact mechanisms of <em>N. sativa</em> and its different derivatives.https://www.rjpharmacognosy.ir/article_99289_f5613bb45b6fb6dd8a7a2a9b5f7857a1.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Bio-guided Fractionation of Centaurea bruguierana subsp. belangeriana Extract Based on Anti-Helicobacter pylori Activity61679926010.22127/rjp.2019.206080.1529ENMahdieh KalkhoraniDepartment of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.0000-0002-8785-939XAbbas HadjiakhoondiDepartment of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Narguss YassaDepartment of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Mohsen AminDepartment of Food and Drug Analysis, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.0000-0002-1477-3616Seyedeh Bahareh DamankashDepartment of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Fatemeh MoradkhaniDepartment of Medicinal chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.0000-00001-9932-3237Mahdi Vazirian*Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.0000-0002-8386-2225Journal Article20191105<strong>Background and objectives:</strong> <em>Centaurea</em> <em>bruguierana</em> subsp. <em>belangeriana</em> (DC.) Bornm. is an annual herb widely distributed in the world. It is used in folk medicine of Iran as an anti-ulcer for gastrointestinal problems. Previous studies have revealed the anti-ulcer effects of the plant extract and in the present study the anti-<em>Helicobacter</em> <em>pylori</em> activity of different fractions, isolated from <em>C. bruguierana</em> subsp. <em>belangeriana</em> was evaluated. Urease and motility inhibition activity were also examined for determination of possible mechanisms. <strong>Method:</strong> Ethanol 80% was used for the extraction. Chloroform, ethyl acetate, and methanol fractions of the total extract were obtained by solid-liquid extraction. All extracts were evaluated against jack bean urease, bacterial swarming and Minimal Inhibitory Concentrations (MICs) were determined using the agar diffusion method. Bio-guided fractionation was performed by isolation and purification of compounds from active fractions using silica-gel open column chromatography by column and thin layer chromatographic methods and identification by spectroscopic data. <strong>Results:</strong> Total extract and chloroform fraction possessed the highest anti-<em>H. pylori</em> activity with MIC 325 300 µg/mL and, respectively. The total extract was the most potent urease inhibitor (IC<sub>50</sub> 250 µg/mL). The motility test confirmed the results by inhibiting swarming at concentrations comparable with IC<sub>50</sub>. The separation and purification of effective compounds of the chloroform extract was performed according to the results; Lupeol (1), Retusin (2), and Apigenin (3) were isolated and identified. <strong>Conclusion:</strong> Our research demonstrated a noticeable anti-<em>H.pylori</em> activity of different fractions from<em>C.bruguierana</em> subsp. <em>belangeriana</em> especially the nonpolar fraction.<br /> <br /> <strong> </strong>https://www.rjpharmacognosy.ir/article_99260_326844d28e4b57be399ae030d385a6b0.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101A Comprehensive Review about Quercus infectoria G. Olivier Gall69779694710.22127/rjp.2019.184177.1494ENFatemeh AskariDepartment of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.0000-0002-1795-7330Amir AzadiDepartment of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.0000-0001-7763-7956Bahia Namavar-JahromiInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.0000-0002-7839-9627Mojgan TansazDepartment of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0002-9348-4635Asghar Mirzapour NasiriDepartment of Natural Resources and Water Management, Khorramabad, Iran.0000-0002-5437-6842Abdolali MohagheghzadehDepartment of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.0000-0002-4873-1449Parmis Badr*Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran.0000-0001-9136-6785Journal Article20190503Due to an interaction between gall wasp <em>Andricus sternlichti</em> Bellido and <em>Quercus infectoria</em> G.Olivier from Fagaceae, the oak galls with a wide range of industrial and pharmaceutical applications are produced. <em>Quercus infectoria</em> galls have been well-known by both ethnopharmacology and traditional medicine of Iran. The aim of current study was a comprehensive collection of Persian scholars' notions and recent findings about medicinal effects of this gall. Sixteen traditional manuscripts of one millennium were sought by two keywords (“Afs” and “Mazu”. Arabic and Persian names of <em>Quercus</em> gall, respectively), and relevant articles till October 2018 were reviewed. In traditional manuscripts, three main dosage forms from gall including decoction, powder, and poultice were found. They had been prescribed for about of thirty disorders. Except for one clinical trial, other articles described related to animal studies and antimicrobial effect evaluation. Since <em>Quercus infectoria</em> gall as an endemic natural product of Iran is a valuable source for export, ethnic usages and pharmaceutical applications, the outcomes of this study can be beneficial for researchers involved in development of natural medications.<br /> https://www.rjpharmacognosy.ir/article_96947_7f7e00d660cd9e68f6b7438d74357480.pdf- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical SciencesResearch Journal of Pharmacognosy2345-44587120200101Citrullus colocynthis: the Most Suggested Herb in Persian Medicine for Management of Low-Back Pain79869693210.22127/rjp.2019.185587.1496ENMohamad SaneiDepartment of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0002-8389-0752Roshanank Mokaberinejad*Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0002-8851-5572Farzin RoozafzaiDigestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Shobeir Rostami AbousaidiDepartment of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Journal Article20190513Low-back pain is a common disease and a considerable economic burden in modern societies. Complementary and alternative therapies for assisting management of pain and disability are sought by a large number of patients. In the present work, the most common herbs used to manage Low-back pain in Iranian traditional medicine (Persian medicine) and current literature has been investigated.Chapters about low-back pain (“Vaja-e Zahr”), and radiculopathy (“Erghonnasa”) and sciatica from Liber Continens (Alhavi) and Canon of Medicine were reviewed. All types of plant usage mentioned in the books including oral, rectal, and topical administration, either alone or in combination were recorded. Descriptive statistics (frequency distributions) were used to report the findings. The current literature were searched with “herbal medicine” and “low-back pain” medical subject heading (MeSH) terms in PubMed, EMBASE, ScienceDirect, Scientific Information Database (in Persian), and Google Scholar databases, to investigate medicinal usage of the most suggested plants.<em>Citrullus</em> <em>colocynthis</em> L. Schrad was the most common plant that Rhazesused in compounds and a significant herb used by Avicenna for management of low-back pain and sciatica. Fruit was the main part and rectal route was the main type of administration of colocynth for low-back pain management.In conclusion, we have proposed a new use of <em>Citrullus colocynthis </em>for management of low-back pain and sciatica according to the evidences from Persian medicine. According to current literature survey, no study has yet investigated or suggested the usage of <em>Citrullus colocynthis </em>for low-back pain management. Further laboratory and clinical studies are required to confirm the safety and efficacy of this plant or its components in low-back pain and sciatica management.https://www.rjpharmacognosy.ir/article_96932_e23af28f0a9c4ba98bfe8a8e1d02d5b3.pdf