TY - JOUR ID - 53360 TI - Evaluation of anti-nociceptive and anti-inflammatory activities of hydroalcoholic extract derived from root of Apium graveolens L. in mice JO - Research Journal of Pharmacognosy JA - RJP LA - en SN - 2345-4458 AU - Ranjbar*, A.M. AU - Vahidi, A. AU - Rezvani, M.E. AU - Ramezani, V. AU - Boroumand, M. AD - Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Herbal Medicine Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Herbal Medicine Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Y1 - 2017 PY - 2017 VL - 4 IS - Supplement SP - 113 EP - 113 KW - anti-inflammation KW - anti-nociceptive KW - celery DO - N2 - Background and objectives: Apium graveolens L. (celery) has been considered as sedative, analgesic, carminative, antispasmodic and diuretic plant in traditional Iranian medicine. The aim of the present study was to evaluate the anti-nociceptive and anti-inflammatory effect of celery root in mice. Methods: Analgesic effect of celery root was determined by two animal models of hot plate and acetic acid writhing test. Anti-inflammatory potential of the extract was also determined by formalin induced ear edema and xylene induced paw edema tests.  Results: The result showed no significant difference between the positive control group and the test group in hot plate test and the most effective dose of celery root was 200 mg/kg, while the frequency of writhings was significantly different in whole test groups in comparison with control group (p<0.05), the extract (100, 200 and 400 mg/kg) significantly suppressed inflammation in formalin induced edema 60 and 120 min after injection. Celery root extract (200 and 400 mg/kg) also demonstrated considerable antiedematogenic effect in xylene test.Conclusion: Celery root showed analgesic and anti-inflammatory effects, which must be related to the flavonoids and resins present in the constituents of celery. UR - https://www.rjpharmacognosy.ir/article_53360.html L1 - https://www.rjpharmacognosy.ir/article_53360_d59e613f40a7441cae935c845096b3b9.pdf ER -