%0 Journal Article %T Chemical Composition and Some Biological Activities of Artemisia marschalliana Essential Oil %J Research Journal of Pharmacognosy %I - The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences %Z 2345-4458 %A Asgharian, Parina %A Zadehkamand, Masumeh %A Delazar, Abbas %A Safarzadeh, Elham %A Asnaashari*, Solmaz %D 2019 %\ 10/01/2019 %V 6 %N 4 %P 71-77 %! Chemical Composition and Some Biological Activities of Artemisia marschalliana Essential Oil %K Artemisia %K DPPH %K GCMS %K heme %K MTT %R 10.22127/rjp.2019.93527 %X Background and objectives: The aerial parts of Artemisia marschalliana Sprengel as an indigenous species of genus Artemisia in the East Azerbaijan province of Iran, was subjected to phytochemical analysis, as well asanti-proliferative, free-radical-scavenging and anti-malarialactivities. Methods: The chemical composition of the essential oil obtained from the aerial parts of A. marschalliana was analyzed by GC/MS (gas chromatography/mass spectrometry) and GC/FID (gas chromatography/ flame ionization detector). The anti-proliferative, anti-oxidant, and anti-malarial activities of the essential oil were assessed by MTT, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and cell-free β-hematin formation assays, respectively. Results: A total of 38 constituents were identified, which represented 95.55% of the oil. The essential oil was characterized by a high content of oxygenated sesquiterpenes. The major components of the oil were spathulenol (38.25%), isoaromadendrene epoxide (8.5%), and caryophyllene oxide (7.31%). The oil exhibited cytotoxic activity against the human breast adenocarcinoma (MCF-7) cell line. The half maximal inhibitory concentration (IC50) of anti-malarial assay was 0.38±0.04 mg/mL; the oil, however, displayed low anti-oxidant activity. Conclusion: These findings will be beneficial for the further development of new chemotherapeutic or anti-malarial agents.   %U https://www.rjpharmacognosy.ir/article_93527_120200d923183d6d6cbf3ff1dcf6e80c.pdf