%0 Journal Article %T Abietane-type diterpenoids from the roots of Salvia tebesana %J Research Journal of Pharmacognosy %I - The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences %Z 2345-4458 %A Eghbaliferiz*, S. %A Asili, J. %A Emami, S.A. %A Tayarani-Najaran, Z. %A Iranshahi, M. %D 2017 %\ 11/01/2017 %V 4 %N Supplement %P 15-15 %! Abietane-type diterpenoids from the roots of Salvia tebesana %K abietane diterpenoid %K mass spectroscopy %K NMR %K Salvia tebesana %R %X Background and objectives: The genus Salvia is one of the largest genera in the family Lamiaceae and represents approximately 1000 species displaying a remarkable diversity.Salvia tebesana Bunge(Lamiaceae) is an endemic medicinal species that grows wild in center of Iran which is locally named “Maryamgoli Tabasi”. Methods: The dried roots (2 kg) were perculated with MeOH at room temperature. Methanol extract was further fractionated to give four different fractions [n-hexane, dichloromethane (CH2Cl2), ethyl acetate (EtOAc) and water (H2O)]. In the next step, to afford the major bioactive compound(s) of the plant, the EtOAC extract was further sub-fractionated by silica gel column chromatography using a mixture of petroleum ether/ethyl acetate with increasing polarity. The different fractions were purified by reversed-phase semi-preparative HPLC. Results: From the ethyl acetate extract, two diterpene quinones with rearranged abietane skeletons, aegyptinones A and B were isolated and their structures were mainly elucidated by 1D and 2D NMR and mass spectroscopy. Conclusion: These compounds have been reported for the first time from this plant. %U https://www.rjpharmacognosy.ir/article_52993_5e2da77ee8ae610c6dd4635781ff0047.pdf