%0 Journal Article %T Efficacy of a Topical Herbal Cream Containing Frankincense Oil, Pumpkin Oil and Licorice Aqueous Extract in Patients with Mild-to-Moderate Plaque Psoriasis: a Randomized Clinical Trial %J Research Journal of Pharmacognosy %I - The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences %Z 2345-4458 %A Fadaei, Fatemeh %A Ayati, Mohammad Hossein %A Firooz, Alireza %A Younespour, Shima %A Abouali, Morteza %A Tabarrai, Malihe %A Shirbeigi*, Laila %D 2022 %\ 01/01/2022 %V 9 %N 1 %P 89-101 %! Efficacy of a Topical Herbal Cream Containing Frankincense Oil, Pumpkin Oil and Licorice Aqueous Extract in Patients with Mild-to-Moderate Plaque Psoriasis: a Randomized Clinical Trial %K Clinical trial %K medicinal plants %K Persian medicine %K Psoriasis %K topical cream %R 10.22127/rjp.2021.291844.1720 %X Background and objectives: Psoriasis is a prevalent, chronic, and inflammatory disorder with good response rates using novel treatment strategies. However, side effects are a limiting factor in long-time treatment. Recent studies have demonstrated that many natural remedies have fewer side effects, and are thus safer options. The aim of this study was to evaluate the efficacy of a novel topical herbal preparation in patients with plaque psoriasis. Methods: This randomized, triple-blind, vehicle-controlled, two-arm parallel trial was conducted in patients with mild-to-moderate plaque psoriasis (psoriasis area & severity index= PASI score< 12). We randomized 108 patients in 1:1 ratio to receive Boswellia-based cream (containing Boswellia spp. ethanolic extract, Boswellia spp. oil, Glycyrrhiza glabra extract, Cucurbita pepo pulp oil) or vehicle cream, both applied as a thin layer on skin lesions twice daily for four weeks. Results: Compared with vehicle, the Boswellia-based cream group showed greater reduction in mean PASI score from baseline to week two and from week two to week four (both p<0.001). After two weeks of therapy, Dermatology Life Quality Index decreased in both groups, but to a greater extent in the intervention group compared with vehicle (p=0.004). From week two to week four, this item showed an additional decrease in Boswellia-based group compared to vehicle (p=0.001). After four weeks of therapy, patients in the Boswellia-based group were more satisfied than patients in vehicle group (median score: 8 in Boswellia-based group and 5 in vehicle, p<0.001). Conclusions: The outcomes showed significant alleviation of psoriasis signs and symptoms with this herbal cream.  %U https://www.rjpharmacognosy.ir/article_140868_f0d38b893a1e09a3da9fa7aaa209b4d4.pdf