@article { author = {Goorani, S. and Zangeneh*, M.M. and Zangeneh, A. and Poorshamohammad, C. and Abiari, M. and Moradi, R. and Najafi, F. and Tahvilian, R.}, title = {Study of wound healing potential of Stevia rebaudiana ethanol extract in male rats}, journal = {Research Journal of Pharmacognosy}, volume = {5}, number = {1}, pages = {23-30}, year = {2018}, publisher = {- The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences}, issn = {2345-4458}, eissn = {2345-5977}, doi = {}, abstract = {Background and objectives: Stevia rebaudiana has been used in medicine as anti-inflammatory, antioxidant, antipyretic, anti-fungal, and antibacterial agent. The present study was conducted to investigate the healing effects of S. rebaudiana ethanol extracts on cutaneous wounds in rats. Methods: Full-thickness excisional wounds (2×2 cm) were induced on the back of 32 rats. The rats were divided into four groups as follows; untreated (control) and treated with 1 mL basal cream, 1 mL S. rebaudiana ethanol extract 10%, and 1 mL tetracycline (3%) for 20 days (short term). Animals of each group were euthanized at 20 day post-injury and wounds were assessed through macroscopic and microscopic analyses. Results: During the experiment, S. rebaudiana indicated a significant reduction in the wound area compared to other groups. Parameters such as arrangement of the healing tissue, re-epithelilization and epithelial formation demonstrated considerable changes when compared to the control. In addition, treatment with S. rebaudiana decreased the total number of cells, fibrocytes/fibroblasts ratio, neutrophils, and lymphocytes and enhanced the number of blood vessels and fibroblasts at 20 day. Conclusion: The present study demonstrated the wound healing activity of S. rebaudiana, lending credence to the folkloric use in the treatment of cutaneous wounds.}, keywords = {ethanol extract,in vivo,Stevia rebaudiana,wound healing}, url = {https://www.rjpharmacognosy.ir/article_54422.html}, eprint = {https://www.rjpharmacognosy.ir/article_54422_4f0951523f4ca15c5ccec9ec604a2ee7.pdf} }