@article { author = {Sharififar, F. and Miri-Moghaddam, M. and Nematollahi-Mahani, S.N. and Forootanfar, H. and Asgharian Rezee, M.}, title = {Cytotoxicity effect of Zataria multiflora Boiss. on two human colon carcinoma cell lines}, journal = {Research Journal of Pharmacognosy}, volume = {4}, number = {4}, pages = {65-70}, year = {2017}, publisher = {- The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences}, issn = {2345-4458}, eissn = {2345-5977}, doi = {}, abstract = {Background and objectives: Natural products are one of the major sources for investigations of novel medicines. Zataria multiflora Boiss (ZM) has shown pharmacological activities especially in gastrointestinal tract; however, there are limited studies about its cytotoxicity effects. In this study, the effect of Zataria multiflora was examined on two colon cancer cell lines (SW-48 and HT-29). Methods: Hydro-alcoholic extract of ZM and its fractions including chloroform, petroleum ether and methanol extract were prepared by warm maceration method. Different concentrations were prepared and examined on SW-48 and HT-29 cell lines using 2-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide (MTT) assay. Results: The results of the present study have shown the cytotoxic effect of some fractions of ZM. The most considerable cytotoxic effect was shown against HT-29 cell line. Also, total ZM extract and the petroleum ether fraction demonstrated cytotoxic effects with IC50 values of 44.22 and 33.42 µg/ml on SW-48 and HT-29 cell lines, respectively. Conclusion: Zataria multiflora was cytotoxic to against colon cancer cell lines HT-29 and SW-48.  }, keywords = {Cytotoxicity,HT-29,SW-48,Zataria multiflora Boiss}, url = {https://www.rjpharmacognosy.ir/article_50410.html}, eprint = {https://www.rjpharmacognosy.ir/article_50410_749433a52101dc0bb5e19d0a9ca9942a.pdf} }