• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Ethical Consideration
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter Telegram
Research Journal of Pharmacognosy
Articles in Press
Current Issue
Journal Archive
Volume Volume 5 (2018)
Volume Volume 4 (2017)
Volume Volume 3 (2016)
Volume Volume 2 (2015)
Volume Volume 1 (2014)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Asghari, G., Zahabi, F., Eskandarian, A., Yousefi, H., Asghari, M. (2014). Chemical composition and leishmanicidal activity of Pulicaria gnaphalodes essential oil. Research Journal of Pharmacognosy, 1(4), 27-33.
G. Asghari; F. Zahabi; A. Eskandarian; H. Yousefi; M. Asghari. "Chemical composition and leishmanicidal activity of Pulicaria gnaphalodes essential oil". Research Journal of Pharmacognosy, 1, 4, 2014, 27-33.
Asghari, G., Zahabi, F., Eskandarian, A., Yousefi, H., Asghari, M. (2014). 'Chemical composition and leishmanicidal activity of Pulicaria gnaphalodes essential oil', Research Journal of Pharmacognosy, 1(4), pp. 27-33.
Asghari, G., Zahabi, F., Eskandarian, A., Yousefi, H., Asghari, M. Chemical composition and leishmanicidal activity of Pulicaria gnaphalodes essential oil. Research Journal of Pharmacognosy, 2014; 1(4): 27-33.

Chemical composition and leishmanicidal activity of Pulicaria gnaphalodes essential oil

Article 5, Volume 1, Issue 4, Autumn 2014, Page 27-33  XML PDF (502 K)
Document Type: Original paper
Authors
G. Asghari1; F. Zahabi2; A. Eskandarian3; H. Yousefi3; M. Asghari4
1Department of Pharmacognosy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
2Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
3Department of Parasitology, faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
4Department of Biotechnology, College of Agriculture & Natural Resources,University of Tehran, Tehran, Iran.
Abstract
Background and objectives: Several natural compounds have been identified for the treatment ofleishmaniasis. Due to a few safe drugs and the side effects caused by available chemotherapy, some new drugs for treatment of leishmaniasis are requested.  The genus Pulicaria (Asteraceae) is represented in the flora of Iran by five species. Phytochemical studies on Pulicaria species have revealed some flavonoids and terpenoids with leishmanicidal activity. In the present investigation chemical composition and leishmanicidal activity of Pulicaria gnaphalodes essential oil have been studied. Methods: The essential oil of the aerial parts of the plant was obtained by Clevenger apparatus and was analyzed by GC/MS. Antileishmanil activity was assessed against promastigoes of Leishmania major. Results:The major components from P. gnaphalodes essential oil have been reported to be geraniol, 1,8-cineole, chrysanthenone, α-pinene, chrystanthenone, α-terpineol and filifolone. The alcohol monoterpenes with contribution of 25.04% constituted the major portion of the essential oil, while hydrocarbon monoterpenes and hydrocarbon sesquiterpenes with contribution of 7.08% and 2.38%, respectively occupied the next rates.In the present experiment the essential oil of P. gnaphalodes progressively inhibited Leishmania major growth in concentrations ranging from 0.125 to 50 µL/mL (parasite culture) in 24 h. The essential oil at 50 µL/mL eliminated the promastigotes at the beginning of treatment. It showed antileishmanial activity in concentration of 1.06 µL/mL and destroyed all parasits in 24 h.  Conclusion: Pulicaria gnaphalodes antileishmanial activity, could suggest the species and constituents as possible lead structures for antileishmanial drug discovery.
Keywords
Essential oil; GC/MS; Leishmania Major; Pulicaria gnaphalodes
Statistics
Article View: 2,317
PDF Download: 3,379
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

web site traffic statistics

 

Journal Management System. Designed by sinaweb.