Tumorigenesis Inhibition of Carnosol From Rosemary: an Insight to Molecular Targeting

Document Type : Original paper

Authors

1 Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

2 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Department of Traditional Medicine, School of Traditional Medicine Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Background and objectives: Anti-proliferative activity of carnosol from Rosemary on malignancies has revealed its potential for cancer therapeutic purposes. Molecular studies such as proteomics could open a new insight in underling mechanisms of anticancer processes of carnosol treatment through analysis of the most relevant modulated proteins in cancer. Methods: Protein-protein interaction (PPI) network analysis of adult T-cell leukemia/lymphoma (ATL) treated with carnosol proteome was conducted. Cyroscape and its plug-ins explored the PPI network construction and its features including centrality and gene ontology. Results: Among 22 differentially expressed proteins (DEPs), 21 individuals were recognized by the STRING database. The queried DEPs and the added first neighbors formed a scale-free network. GAPDH, TPI1, ENO1, and PGK1 were identified as the hub-bottlenecks of the PPI network of carnosol-treated ATL. Conclusion: ALDOA, PFKFB3, PKM2, and LDHA and related metabolic processes are targets of anticancer compounds of rosemary extract; however, more investigation is suggested.

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