Anti-Anxiety Effect of Salvia hypoleuca

Document Type: Short communication

Authors

1 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

2 Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

3 Department of Pharmacognosy, Faculty of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran

4 Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

5 Department of Pharmacognosy and Biotechnology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

10.22127/rjp.2020.216084.1550

Abstract

 Background and objectives: Anxiety is a chronic and common disorder worldwide and impairs the quality of life of affected people. Herbal medicines have long been used to treat CNS related disorders. Salvia species are important medicinal plants that have shown various pharmacologic activities including CNS effects. Salvia hypoleuca is an annual and herbaceous plant which is endemic to Iran. The aim of this study was to evaluate the anxiolytic activity of the hydro-alcoholic, n-hexane, ethyl acetate and methanol extract of S. hypoleuca in mice. Methods: n-hexane, ethyl acetate, methanol and hydroalcholic extracts were prepared from aerial parts of Salvia hypoleuca. Anxiolytic activity of the extracts was evaluated using open field and hole-board tests. The mice were randomly divided into different groups and were treated with normal saline, diazepam, and the extracts of Shypoleuca (500 mg/kg, ip). Results: The results of open field and hole-board tests showed that treatment of mice with the hydro-alcoholic and methanol extracts of Shypoleuca(500 mg/kg, ip) produced a significant anxiolytic effect as compared to the normal control group.  Conclusion: This study demonstrated that the hydro-alcoholic and methanol extracts of aerial parts of S. hypoleuca have anti-anxiety activity. The isolation and identification of the active compounds of the effective extracts are suggested.

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