TY - JOUR ID - 53280 TI - Determination of blood glucose lowering and metabolic effects of Mespilus germanica L. extract on normal and streptozocin-induced diabetic Balb/c mices JO - Research Journal of Pharmacognosy JA - RJP LA - en SN - 2345-4458 AU - Yaghubi Beklar, S. AU - Hamzeh, M. AU - Ataee*, R. AD - Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. AD - Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran. AD - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Y1 - 2017 PY - 2017 VL - 4 IS - Supplement SP - 70 EP - 70 KW - Diabetes KW - Flavonoids KW - Mespilus germanica KW - Mice DO - N2 - Background and objectives: The serum glucose lowering, normalization animal body weight and antioxidative stress effects of Mespilus germanica L. leaf extract were investigated in normal and streptozotocin-induced Balb/C mices. Methods: The leaves of M. germanica were extracted using acetone/water (70:30) by percolation method and concentrated using rotary-evaporator device and its total phenolics and flavonoids content were determined using Folin-Ciocalteu and aluminum chloride methods, respectively. The study was conducted on forty eight matured male Balb/C mices (20-30 g) divided into 6 groups (n=8). Diabetes mellitus was induced by single intraperitoneal injection of 35 mg/kg of streptozotocin (STZ). Extracts of Mespilus germanica were used orally at the dose of 50, 100 and 200 mg/kg body weight per day for 21 days. Results: Oral administrations of the Mespilus germanica L. leaf extract significantly decreased serum glucose, oxidative stress and lipid peroxidation and maintained animal body weight during treatment period (p<0.05) compared to metformin (200 mg/kg) in over 100 mg/kg, 200 mg/kg and 50 mg/kg dosages, respectively. Conclusions: It was concluded that the plant and its phytochemicals could be considered as new appropriate therapeutic options for diabetes mellitus. UR - https://www.rjpharmacognosy.ir/article_53280.html L1 - https://www.rjpharmacognosy.ir/article_53280_fe0e482dace30aa9fd222128b18ae2bc.pdf ER -