TY - JOUR ID - 4761 TI - Anticonvulsant activity of Astragalus squarrosus Bunge JO - Research Journal of Pharmacognosy JA - RJP LA - en SN - 2345-4458 AU - Shafaroodi, H. AU - Zareie, H.R. AU - Asgarpanah, J. AD - Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran, Iran. Y1 - 2014 PY - 2014 VL - 1 IS - 2 SP - 45 EP - 49 KW - anticonvulsant activity KW - Astragalus squarrosus KW - clonic seizure KW - Fabaceae DO - N2 - The anticonvulsant activity of Astragalus squarrosus total extract was assessed in pentylenetetrazole (PTZ)-induced convulsion in mice, with diazepam as the standard drug, while mechanistic studies were also conducted using flumazenil, a GABA A-benzodiazepine receptor complex site antagonist. The extract produced protection against convulsion at 400 mg/kg, comparable with protection of benzodiazepine (diazepam). The mean onset and percentage protection against convulsion in extract-treated mice were reduced by flumazenil. The results suggest that A. squarrosus extract possesses biologically active constituent(s) that have anticonvulsant activity which supports the ethnomedical claims of its use in the management of seizure. UR - https://www.rjpharmacognosy.ir/article_4761.html L1 - https://www.rjpharmacognosy.ir/article_4761_0f0a3cc5bab8e0dfd4d6c5f68ae06783.pdf ER -