%0 Journal Article %T Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial %J Research Journal of Pharmacognosy %I - The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences %Z 2345-4458 %A Zarghami, Mehran %A Chabra, Aroona %A Azadbakht*, Mohammad %A Khalilian, Alireza %A Asghar Hoseini, Ali %D 2018 %\ 07/01/2018 %V 5 %N 3 %P 15-20 %! Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial %K Asperugo procumbens %K badranjbuyeh %K depression %K fluoxetine %R 10.22127/rjp.2018.64860 %X Background and objectives: Aseprugo procumbens is used as antianxety and depression in Iranian traditional medicine; however no clinical trial has been performed about these properties. The aim of this study was to evaluate the antidepressant efficacy and safety of hydroalcoholic extract of A. procumbens. Methods: In this double blind study, 30 outpatients with mild to moderate depressive disorder (according to DMS-IV-TR criteria who had a score of 18-25 on the Hamilton Depression Rating Scale (HDRS) were randomly divided in two group, 1) received 10 mg fluoxetine capsule, 2) received 1.2 g dried extract of A. procumbens capsule (6 mg flavonoid,) orally per day. Patients were followed up for 6 weeks; the recovery process was assessed by the HDRS in weeks 0, 2, 4 and 6. Results: A significant decrease in HDRS was observed in both groups after the fourth week. After the sixth week, fluoxetine had a greater anti-depressant activity than A. procumbens (p value =0.03). There were no significant differences in terms of adverse effects in both groups. Conclusions: The hydroalcoholic extract of A. procumbens can be considered as an effective and safe remedy for mild to moderate depressive disorder.   %U https://www.rjpharmacognosy.ir/article_64860_3f60b43d8238c9a451f59d5fa6d87dd9.pdf