%0 Journal Article %T Cytotoxic activity of plants from Ardebil province %J Research Journal of Pharmacognosy %I - The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences %Z 2345-4458 %A Eslami Tehrani, B. %A Shahrestani, R. %A Bahmani, B. %A Mosaddegh, M. %A Nader*, N. %D 2017 %\ 11/01/2017 %V 4 %N Supplement %P 53-53 %! Cytotoxic activity of plants from Ardebil province %K Ardebil %K Cytotoxicity %K medicinal plants %R %X Background and objectives: Cancer is the third leading cause of mortality and morbidity in Iran and kills out about 30000 people a year. The drugs used to treat cancer have many side effects. So developing novel and effective drugs with lower side effects has a great importance. Located in the north-west of Iran, Ardebil province has a rich plant diversity which the biological effects of most of them are unknown. In this study, the cytotoxic effects of 18 plants collected from Ardebil have been investigated. Methods: The cytotoxic effect of total methanol extract and petroleum ether, chloroform and methanol fractions were investigated by using MTT assay against 4 selected human cancer cell lines MCF7, HepG-2, A-549, HT-29 and also a normal cell line, MDBK. Results: Total methanol extract and chloroform fraction of the aerial parts of Onopordon acanthium showed significant cytotoxic effect against all cell lines with 12.51≤ IC50 ≤ 55.72 and 6.49≤IC50≤31.5, respectively. Conclusion: The plant could be a candidate for further investigations on its cytotoxicity mechanism and also identification of active ingredients.   %U https://www.rjpharmacognosy.ir/article_53256_94b4585837ea8754459ec403693d0799.pdf