Imaginative Professor
Abdolali
Mohagheghzadeh*
Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
author
text
article
2019
eng
Avicenna (980-1037 A.D.) in his famous “Isharat va Tanbihat” text indicated that human pleasure should be studied in four stages: sense, imagination, estimation and wisdom [1]. Imagination has received much interest in the recent publication [2], which possesses a deep influence on pleasure and resilience in complex and hard professions like academic staff with so many responsibilities, such as teaching, consulting, researching, group managing, and of course personal tasks. As an under- and post-graduate mentee of late Professor Dr. Seyed Hadi Samsam-Shariat (emeritus professor of Isfahan School of Pharmacy), I had the chance to live in the imaginative world of his professorship. Teaching and training: None of Isfahan pharmacy students would forget his medicinal plants' lab atmosphere, imaginative well-designed natural products collected from local “Attaries”, common medicinal plants' herbaria vouchers, serial microscopes for examining herbal powders as well as a creatively contrived program for continuous teaching students by means of slides, authentic and unknown samples. This program was completed by visiting botanical garden, a student project for collecting and identifying herbal market as well as ethnopharmacologic samples, which was performed in a serious discipline. Such lab world encourages students' vitality and enthusiasm for following herbal products applications as the future pharmacy technical assistances and in other positions. Research and publication: He published several texts and supervised around one hundred Pharm.D. and Ph.D. theses in the vast field of natural products, including ethnopharmacology, traditional medicine, natural product formulating, quality control and clinical trials of medicinal plants, and related subjects. As the father of Iranian ethnopharmacology, he did document native beliefs in phytotherapy from different geographical regions by conducting Pharm.D. theses. Such encountering with natives' information on local and indigenous medicinal plants and subsequent lab experiences was very imaginative and promising for young students. Morality and group managing: He had a serious prestige, as a hard-working professor who began before students early in the morning, and he continued work till late evening. He did manage department of Pharmacognosy very well, in an unmerciful atmosphere against medicinal plants dialogue. Such deportment from a senior of faculty had a deep influence on feeling identity and self-confidence in disposed students. Manufacturing: He, even after retirement, continued formulation and production of medicinal herbal products in a science-based company, as the last lesson of pharmacy teaching. Apprentice: He was a permanent role model directly or indirectly for generations of students who did in turn contribute further in cultivating pharmacy students, establishing traditional Iranian pharmacy and medicine program, designing medicinal plant research centers and associations, managing quality control programs and setting up science-based companies. In sum, late Professor Samsam-Shariat was a key contributor in the growing scientific tree of Iranian medicinal plants by composing students' imagination framework. The famous poet “Saadi Shirazi” (ca 1200 A.D.) well composed the imaginary power of a mentor: I cannot façadeaught which its imagination has not been before composed by the teacher. مرا صورتی بر نیاید زدست که نقشش معلم ز بالا نبست References 1. Avicenna H. Isharat va tanbihat. Trans. Malekshahi H. Tehran: Soroush Press, 2009. 2. Black DB. Imagination and estimation: Arabic paradigms and western transformations. Topoi. 2000; 19(1): 59-75.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
https://www.rjpharmacognosy.ir/article_93484_a305914555441f50f847f11240eecd34.pdf
dx.doi.org/10.22127/rjp.2019.93484
Preparation of a Topical Product from Allium sativum Retrieved from Iranian Traditional Medicine
Maryam
Jahandideh
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
author
Paria
Kharazi
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
author
Zahra
Jafariazar
Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
author
Shirin
Fahimi*
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
text
article
2019
eng
Background and objectives: Garlic (Allium sativum L.) oil has been introduced in Iranian traditional medicine (ITM) as an effective topical agent for urine dribbling. Additionally, the beneficial effects of garlic on prostatic proliferation have been revealed in recent studies. The purpose of this research was formulation of a topical ointment using garlic oil proposed by ITM and quality control of the product. Methods: Garlic oil was prepared according to ITM instructions and analysed using GC/MS method. In order to formulate garlic ointment, several experimental formulations were examined. Microbial tests as well as physical assessments including thermal stability evaluation and study of rheological behaviour were performed on the final product. Results: GC/MS analysis of garlic oil showed the presence of dialyl trisulfide, one of the major organo-sulfur components of garlic. The herbal ointment containing garlic oil (70%), white petrolatum (23.7%) and white beeswax (6%), showed suitable physical properties as well as plastic tixotropic behaviour and was free of any microbial contamination. Conclusion: Regarding the modern evidences about the beneficial effects of garlic and its sulphur compounds on improvement of BPH and prevention of prostate cancer, garlic ointment could be an appropriate candidate for studies in the field of prostate related diseases with respect to its traditional use in ITM.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
3
6
https://www.rjpharmacognosy.ir/article_93491_0f32a4dd8ec5e7e75c4f4a5ab6d534d9.pdf
dx.doi.org/10.22127/rjp.2019.93491
Prediction of Coffee Effects in Rats with Healthy and NAFLD Conditions Based on Protein-Protein Interaction Network Analysis
Majid
Rezaei-Tavirani
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Mostafa
Rezaei Tavirani
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Mona
Zamanian Azodi*
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Zahra
Akbari
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Homa
Hajimehdipoor
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
text
article
2019
eng
Background and objectives: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition. On the other hand, coffee consumption has shown promising for gastrointestinal diseases. Detection of the most valuable biomarkers of decaffeinated coffee treatment in healthy and non-alcoholic fatty liver disease conditions was the aim of the present study. Methods: A previous proteomics study about effect of decaffeinated coffee (1.5 mL daily drinking coffee for two months) on protein expression change of rat liver was selected for protein-protein interaction (PPI) network analysis via Cytoscape v.3.7.1 and the related applications. The most central proteins with regards to a high degree and betweenness centralities in the coffee treatment condition of healthy and NAFLD were then analyzed by ClueGO for biological process (BP) derivation. Results: HSPA5, HSPA4, HSPA9, HSPA7, PARK7, HSP90AA1, P4HB, PRDX1, and PDIA3 were introduced as central proteins, which are involved in folding and antioxidant activities. Conclusion: There is a complicated combination of the components in coffee; some elements are involved in liver protection against NAFLD and the others are in contrast.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
7
15
https://www.rjpharmacognosy.ir/article_93500_ac0b4e714f35039692e4a14291b41e44.pdf
dx.doi.org/10.22127/rjp.2019.93500
Acute Toxicity of Aeollanthus pubescens Essential Oil with High Antimicrobial Potential against Multidrug Resistant Bacteria Isolated in Poultry Farms in Benin
Philippe
Sessou*
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
Laboratory of Study and Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Mahudro
Yovo
Laboratory of Study and Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Rodrigue
Towanou
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Yannick
Ayihou
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Gwladys S.
Komagbe
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Justin
Adinci
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Bruno
Ayaovi Yaovi
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Oscar
Nestor Aguidissou
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Maximin
Senou
Experimental and Clinical Biology Laboratory, National School of Applied Biosciences and Biotechnology, National University of Sciences, Technology, Engineering and Mathematics, P.O Box 14 Dassa-Zoume, Benin.
author
Guy
Alain Alitonou
Laboratory of Study and Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Félicien
Avlessi
Laboratory of Study and Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Souaïbou
Farougou
Research Unit on Communicable Diseases, Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
Dominique
Sohounhloue
Laboratory of Study and Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin.
author
text
article
2019
eng
Background and objectives: The present work aimed to evaluate the acute toxicity of Aeollanthus pubescens essential oil, whose antimicrobial activity has been proven in vitro by previous studies and to examine the effects of this essential oil on the biochemical parameters (transaminases ALT and AST, urea, creatinine and cholesterol) and hematological and histological factors in Wistar rats subjected to this volatile oil. Methods: Nine male Wistar rats, 12 weeks old weighing more than 140 g were divided into three groups of three rats each; group one normal control rats; group two normal rats which received the extract of A. pubescens by gavage at a dosage of 2000 mg/kg of body weight and finally gropup three consisting of normal rats receiving the extract of A. pubescens by intramuscular injection at a dosage of 2000mg/kg body weight. The duration of the experiment was 14 days. Results: At the end of the study, the essential oil of A. pubescens did not cause any mortality in the experimental rats, which indicated that the extract did not exhibit acute toxicity at this dose. Biochemical and hematological analyses revealed no adverse effects (p>0.05) on the hepatic, renal, lipid and hematological parameters measured in these animals. Histological examination showed no alteration of the hepatic and renal structures. Conclusion: This oil can be considered generally recognized as safe at the experimental dosage and can be used in the fight against pathologies of bacterial origin.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
17
26
https://www.rjpharmacognosy.ir/article_93503_ab030bec38e186c770c4b3be0c14223a.pdf
dx.doi.org/10.22127/rjp.2019.93503
Preparation of a Traditional Poly Herbal Gel for Abnormal Vaginal Discharge
Maedeh
Rezghi
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Homa
Hajimehdipoor
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Sara
Zakerin
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Shirin
Fahimi
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
text
article
2019
eng
Background and objectives: Plants are usually used for treatment of different diseases according to their traditional application. The use of the plant based medications is increasingly becoming popular all over the world. Traditional herbal medicines should be transformed into new forms to make better acceptance and more comfortable use by patients. The aim of the present study was to formulate a poly herbal gel based on Iranian traditional medicine (ITM), and determine its physicochemical characteristics. Methods: The gel formulation consisted of Boswellia spp., Carum carvi L., Punica granatum L. and Myrtus communis L. extracts. The product was evaluated for the physicochemical parameters. The laboratory stability tests, microbiological tests and rheological behavior were performed on the gel. Additionally, total tannin content of the gel was measured as pyrogallol using Folin-Ciocalteu reagent and hide powder. Results: Stability and physicochemical evaluations as well as microbiological tests showed that the prepared formulation was stable towards physical changes with no growth of pathogenic microorganisms. Moreover, it represented plastic behavior which is in favor of a topical product and alsototal tannins contents were determined to be 0.27 % in the gel. Conclusion: The product was acceptable due to its physical characterisitcs and so appropriate for topical use. Regarding the antibacterial, antifungal and anti-inflammatory properties of the medicinal herbs in the gel and also, the role of tannins as astringent agents, this formulation could be a suitable candidate for abnormal vaginal discharge with regards to its traditional application in ITM.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
27
35
https://www.rjpharmacognosy.ir/article_93506_aa8354b654e43092ce4bdf14b1c9197f.pdf
dx.doi.org/10.22127/rjp.2019.93506
Effect of Roasting Process on Sesamin and Sesamol Contents of Sesame (Sesamum indicum L.) from Different Parts of Iran
Marzieh
Mokhber
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran
author
Seyed Ali
Keshavarz
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
author
Farzad
Shidfar
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
author
Zahra
Nazem Bokaee
Department of Plant Sciences, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
author
Zohreh
Eftekhari
Research & Development Department, Research & Production Complex, Pasteur Institute of Iran, Tehran, Iran.
author
Abbas
Hadjiakhoondi*
Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
author
text
article
2019
eng
Background and objectives: Sesame (Sesamum indicum L.) seeds have been a well-known oil crop in the world for many centuries. Lignans are functionally important compartments of sesame. Sesamin and sesamol are the main sesame lignans, which have recently shown various activities with health benefits, like anti-oxidative, anti-proliferative, anti-atherosclerotic, anti-inflammatory and anticancer effects. The aim of this study was determination of sesamin and sesamol concentration in sesame seeds from three different regions of Iran with diverse climatic conditions (Dezful, Ardakan and Neka). In addition, the effect of roasting process on sesamin and sesamol content were investigated. Methods: Analysis of sesamin and sesamol was performed using the mobile phase water: methanol (70:30) on a reversed phase ACE C18 with flow rate of 0.6 mL/min and UV detection at 290 nm. Results: HPLC analysis revealed that the highest content of sesamin (1.156±0.002 mg/g of seeds) and sesamol (2.393±0.002 mg/g of seeds) were observed in roasted Dezful seeds samples and hulled roasted Dezful sesame seeds, respectively. The amount of sesamin and sesamol in roasted seeds was higher than unroasted samples. Conclusion: The present study showed that the roasting process and hot semi-arid climate increase the content of lignans in sesame seeds. Consuming sesame seeds with such characteristics will improve dietary lignan intake and has nutritive value. Moreover, sesame seed characterized by the highest amount of sesamin and sesamol is more strongly suggested for achieving biological properties of these components.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
37
43
https://www.rjpharmacognosy.ir/article_93509_b450fcd12833bcda34b37227bb41d45d.pdf
dx.doi.org/10.22127/rjp.2019.93509
Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice
Elham
Hakimizadeh
Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
author
Faezeh
Jandaghi
Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
author
Mojdeh
Hajmohammadi
Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
author
Iman
Fatemi
Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
author
Ayat
Kaeidi
Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
author
Ali
Shamsizadeh
Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
author
Mohammad
Allahtavakoli*
Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
author
text
article
2019
eng
Background and objectives: Menopause is associated with depression as well as emotional and memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on depression, cognitive function, anxiety and physical power in ovariectomized mice was investigated. Methods: In the current study, fifty female mice were used. They were aliquoted into five groups: control, ovariectomy (OVX), ovariectomy + DMSO, ovariectomy +10 mg/kg pistachioextract and Ovariectomy +100 mg/kg pistachio extract. In order to prepare the required extract, pistachio nuts were powdered (100 g) and macerated in 1 L of ethanol (80%) for 72 h. Pistachio extract was used orally once a day in ovariectomized mice for sixty days. Anxiety, depression, working memory and physical power were evaluated by the Elevated plus-maze (EPM) test, Forced swimming test (FST), Y maze and swimming exhaustion test, respectively. Results: The results showed that extract of pistachio (more potentially at the dose of 100 mg/kg) decreased anxiety-like behaviors and depression; besides, increase in working memory and physical power was observed in the ovariectomized mice. Conclusion: The findings of the current investigation suggest that pistachio extract could be used as a potential strategy for the attenuation of ovariectomy-related manifestation
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
45
51
https://www.rjpharmacognosy.ir/article_93515_5a29bf5c90ed91f497fa61f3cba816b2.pdf
dx.doi.org/10.22127/rjp.2019.93515
Formulation of a Traditional Polyherbal Product to a Standard Pharmaceutical Syrup and Development of Its Quality Control Methods
Maedeh
Rezghi
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Seyed Alireza
Mortazavi*
Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Rasool
Choopani
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Shirin
Fahimi
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Mohammad Abbas
Sheihkoleslami
Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Maryam
Hamzeloo-Moghadam
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
text
article
2019
eng
Background and objectives: People interest in traditional medicine has increased recently; however, traditional herbal medicines should be transformed into modern forms of medicine to increase patient acceptance. In this investigation, a polyherbal traditional combination “Monzej-e-balgham” has been based on according to Iranian traditional medicine (ITM) manuscripts and its quality control evaluations have been performed. Methods: The main ingredients of the formulation including Vitis venifera L., Ficus carica L., Foeniculum vulgare Mill., Glycyrrhiza glabra L., Adiantum capillus-veneris L., Rosa damascena Herrm. and Onopordum acanthium L. were crushed, mixed and extracted with distilled water by decoction method. The mixture was used to prepare formulations of the syrup. Physicochemical, microbiological properties and rheological behavior of the syrup were studied and total phenolics content of the formulation was determined. The syrup was evaluated in accelerated stability test during 6 months. Results: The product was light brown semitransparent syrup with appropriate taste and odor. There was no cap locking and precipitation. Dry residue, sedimentation, pH, viscosity, density and total phenolics were found to be 14.82%, 0.015%, 5.40, 4.6 cP, 1.076 g/mL and 127.34 mg/100 mL, respectively. Microbial evaluations of syrupwere consistent with the WHO protocol. The rheogram of the product represented the Newtonian behavior. In the accelerated stability tests, no significant changes were observed. Total phenolics content reduced to 2.50% within 6 months in 40 ºC. Conclusion: The outcome of this research was a pharmaceutical standardized formulation from the traditional “Monzej-e-balgham” which supports the idea of drug discovery based on traditional knowledge.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
53
59
https://www.rjpharmacognosy.ir/article_93523_5058fccab3685a4a29a3815bafb87f9b.pdf
dx.doi.org/10.22127/rjp.2019.93523
Assessment of the Hepatoprotective Activity of Tragopogon graminifolius DC. Aqueous Extract on CCl4- Induced Hepatotoxicity in Mice
Mohammad Mahdi
Zangeneh*
Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
author
Akram
Zangeneh
Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
author
Reza
Tahvilian
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
author
Rohallah
Moradi
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
author
text
article
2019
eng
Background and objectives: Tragopogon graminifolius DC. is widely used in Iranian traditional medicine as a gastro-protective and wound healer agent. In the present study the hepatoprotective property of T. graminifolius DC. aqueous extract (TGAE) was investigated against carbon tetrachloride (CCl4) induced hepatocellular injury in mice. Methods: Fifty male mice were divided into five groups (n=10). Group 1 (control) received 1 ml/kg olive oil intraperitoneally (i.p.) and distilled water orally; Group 2 (untreated) received CCl4 (50% in olive oil, 1 ml/kg; i.p.); Groups 3, 4 and 5 received CCl4 and 30, 90 and 270 mg/kg of TGAE (TGAE30, TGAE90 and TGAE270), respectively. At the end of the 45-day treatment, the mice of all groups were euthanized, then blood and liver samples were collected for biochemical and histological parameters analysis. The data was analyzed by one way variance analysis and Duncan’s test using SPSS 21. Results: Different doses of TGAE (especially TGAE270) could significantly (p≤0.05) reduce the raised levels of ALP, AST, ALT, Cholesterol, LDL and increased HDL, SOD, CAT as compared to the untreated group. The weight and volume of the hepatic structures decreased significantly (p≤0.05) in several doses of TGAE (especially TGAE270) when compared to the untreated group. Conclusion: The results of the present study showed that under the present experimental conditions, TGAE indicated hepatoprotective abilities against CCl4 induced liver damage in mice.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
61
69
https://www.rjpharmacognosy.ir/article_93525_9d4089f86f4c55afd6815c3448f380d8.pdf
dx.doi.org/10.22127/rjp.2019.93525
Chemical Composition and Some Biological Activities of Artemisia marschalliana Essential Oil
Parina
Asgharian
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pharmacognosy, Facullty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
author
Masumeh
Zadehkamand
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
author
Abbas
Delazar
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pharmacognosy, Facullty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
author
Elham
Safarzadeh
Department of Microbiology & Immunology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
author
Solmaz
Asnaashari*
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
author
text
article
2019
eng
Background and objectives: The aerial parts of Artemisia marschalliana Sprengel as an indigenous species of genus Artemisia in the East Azerbaijan province of Iran, was subjected to phytochemical analysis, as well asanti-proliferative, free-radical-scavenging and anti-malarialactivities. Methods: The chemical composition of the essential oil obtained from the aerial parts of A. marschalliana was analyzed by GC/MS (gas chromatography/mass spectrometry) and GC/FID (gas chromatography/ flame ionization detector). The anti-proliferative, anti-oxidant, and anti-malarial activities of the essential oil were assessed by MTT, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and cell-free β-hematin formation assays, respectively. Results: A total of 38 constituents were identified, which represented 95.55% of the oil. The essential oil was characterized by a high content of oxygenated sesquiterpenes. The major components of the oil were spathulenol (38.25%), isoaromadendrene epoxide (8.5%), and caryophyllene oxide (7.31%). The oil exhibited cytotoxic activity against the human breast adenocarcinoma (MCF-7) cell line. The half maximal inhibitory concentration (IC50) of anti-malarial assay was 0.38±0.04 mg/mL; the oil, however, displayed low anti-oxidant activity. Conclusion: These findings will be beneficial for the further development of new chemotherapeutic or anti-malarial agents.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
71
77
https://www.rjpharmacognosy.ir/article_93527_120200d923183d6d6cbf3ff1dcf6e80c.pdf
dx.doi.org/10.22127/rjp.2019.93527
Therapeutic Activities and Phytochemistry of Physalis Species Based on Traditional and Modern Medicine
Fatemeh
Mirzaee
Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
author
Amir
Saeed Hosseini
Traditional and Complementary Medicine Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
author
Romina
Askian
Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
author
Mohammad
Azadbakht*
Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
author
text
article
2019
eng
Physalis, the fifth largest genus of the Solanaceae family, consists many species which are used as food and natural remedies. Phytochemical investigations on Physalis species have led to characterization of important secondary metabolites such as withaphysalins, physalins and phytosterols which are responsible for wide range of pharmacological effects such as potent cytotoxic activity against various type of human cancer cell lines, immunomodulatory and cancer chemopreventive effects. Theyare widely used in the indigenous system of medicine for treatment of kidney and urinary disorders, leishmaniasis, inflammations, skin infections and etc. Based on Iranian traditional medicine texts, Physalis is effective for treatment of several disorders such as asthma, liver, kidney and bladder dysfunctions, wounds, hemorrhoids, and helminthic diseases. Based on recent surveys, many of the above properties have not been investigated so far except the for the healing effects on liver dysfunction. This review might be a starting point for the development of the new therapeutic applications and more investigations on Physalis species in the future.
Research Journal of Pharmacognosy
- The Iranian Society of Pharmacognosy
- Shahid Beheshti University of Medical Sciences
2345-4458
6
v.
4
no.
2019
79
96
https://www.rjpharmacognosy.ir/article_93529_dca970862a9a8acb34796622b6d6f22b.pdf
dx.doi.org/10.22127/rjp.2019.93529