[1] Alanko J, Riutta A, Holm P, Mucha I, Vapaatalo H, Metsä-Ketelä T. Modulation of arachidonic acid metabolism by phenols: relation to their structure and antioxidant/prooxidant properties. Free Rad Biol Med. 1999; 26(1): 193-201.
[2] Alqasoumi S. Gastric antisecretory and antiulcer effects of ajowan Carum copticum in rats. Afr J Pharm Pharmacol. 2011; 5(5): 572-576.
[3] Anilakumar KR, Saritha V, Khanum F, Bawa AS. Ameliorative effect of Ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Food Chem Toxicol. 2009; 47(2): 279-282.
[4] Avicenna. Al qanun fil tibb. New Delhi: Jamia Hamdard Printing Press, 1998.
[5] Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritabl bowel syndrome. Gastroenterology. 2004; 126(3): 693-702.
[6] Trusheva B, Trunkova D, Bankova V. Different extraction methods of biologically active components from propolis: a preliminary study. Chem Cent J. 2007; Article ID 17880743.
[7] Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72: 248-254.
[8] Czéh B, Müller-Keuker JI, Rygula R, Abumaria N, Hiemke C, Domenici E, Fuchs E. Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology. 2007; 32(7): 1490-1503.
[9] Darvish-Damavandi M, Nikfar S, Abdollahi M. A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome. World J Gastroenterol. 2010;16(5): 547-553.
[10] Drossman DA, Thompson WG. The irritable bowel syndrome: review and a graduated multicomponent treatment approach. Ann Intern Med. 1992; 116(12): 1009-1016.
[11] Duke J. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton: CRC Press,1992.
[12] Ford AC, Brandt LJ, Young C, Chey WD, Foxx-Orenstein AE, Moayyedi P. Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol. 2009; 104(7): 1831-1843.
[13] Funatsu T, Takeuchi A, Hirata T, Keto Y, Akuzawa S, Sasamata M. Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats. Eur J Pharmacol. 2007; 573(1-3): 190-195.
[14] Gersbach PV, Reddy N. Non-invasive localization of thymol accumulation in Carum copticum (Apiaceae) fruits by chemical shift selective magnetic resonance imaging. Ann Bot. 2002; 90(2): 253-257.
[15] Liebregts T, Adam B, Bredack C, Roth A, Heinzel S, Lester S, Downie-Doyle S, Smith E, Drew P, Talley NJ, Holtmann G. Immune activation in patients with irritable bowel syndrome. Gastroenterology. 2007; 132(3): 913-920.
[16] Camilleri M, Choi MG. Irritable bowel syndrome. Aliment Pharm Ther. 1997;11(1): 3-15.
[17] Miladi H, Zmantar T, Kouidhi B, Al Qurashi YMA, Bakhrouf A, Chaabouni Y, Mahdouani K, Chaieb K. Synergistic effect of eugenol, carvacrol, thymol, p-cymene and γ-terpinene on inhibition of drug resistance and biofilm formation of oral bacteria. Microb Pathog. 2017; 112: 156-163.
[18] Tariq M, Gore M , Aruna K. Antibacterial and synergistic activity of ethanolic Ajwain (Trachyspermum ammi) extract on ESBL and MBL producing uropathogens. Int J Pharm Sci. 2014; 6(6): 278-284.
[19] Zarshenas MM, Moein M, Mohammadi Samani S, Petramfar P. An overview on Ajwain (Trachyspermum ammi) pharmacological effects; modern and traditional. J Nat Remedies. 2014; 14(1): 98-105.
[20] Mozaffari Sh, Esmaily H, Rahimi R, Baeeri M, Sanei Y, Asadi-Shahmirzadi A, Salehi-Surmaghi MH, Abdollahi M. Effects of Hypericum perforatum extract on rat irritable bowel syndrome. Pharmacogn Mag. 2011; 7(27): 213-223.
[21] Nakhai LA, Mohammadirad A, Yassa N, Minaie B, Nikfar S, Ghazanfari G, Zamani M J, Dehghan G, Jamshidi H, Shetab Boushehri V, Khorasani R, Abdollahi M. Benefits of Zataria multiflora Boiss. in experimental model of mouse inflammatory bowel diseas. Evid Based Complement Alternat Med. 2007;4(1): 43-50.
[22] Nikfar S, Rahimi R, Rahimi F, Derakhshani S, Abdollahi M. Efficacy of probiotics in irritable bowel syndrome: a metaanalysis of randomized, controlled trials. Dis Colon Rectum. 2008; 51(12): 1775-1780.
[23] Pavela R. Acute toxicity and synergistic and antagonistic effects of the aromatic compounds of some essential oils against Culex quinquefasciatus Say larvae. Parasitol Res. 2015; 114(10): 3835-3853.
[24] Ponferrada A, Caso JR, Alou L, Colón A, Sevillano D, Moro MA, Lizasoain I, Menchén P, Gómez-Lus ML, Lorenzo P, Cos E, Leza JC, Menchén L. The role of PPAR gamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. Gastroenterology. 2007; 132(5): 1791-1803.
[25] Zamani MJ, Sharifzadeh M, Rezaie A, Mashayekhi F, Abdollahi M. Effects of sildenafil on rat irritable bowel syndrome. Therapy. 2005; 2(2): 237-242.
[26] Qureshi AA, Kumar KE. Phytochemical constituents and pharmacological activities of Trachyspermum ammi. Plant Arch. 2010;10(2): 955-959.
[27] Rahimi R, Nikfar S, Abbdollahi M. Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. Clin Ther. 2008; 30(5): 884-901.
[28] Rahimi R, Nikfar S, Abdollahi M. Selective serotonin reuptake inhibitors for the management of irritable bowel syndrome: a meta-analysis of randomized controlled trials. Arch Med Sci .2008; 4(1): 71-76.
[29] Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis. World J Gasteroenterol. 2009; 15(13): 1548-1553.
[30] Ramaswamy S, Sengottuvelu S, Sherief SH, Jaikumar S, Saravanan R, Prasadkumar C, Sivakumar T. Gastroprotective activity of ethanolic extract of Trachyspermum ammi fruit. Int J Pharm Biosci. 2010; 1(1): 1-15.
[31] Ranjan B, Manmohan S, Singh SR, Singh RB. Medicinal uses of Trachyspermum ammi: a review. Pharmacogn Rev. 2012; 6(11): 56-60.
[32] Rezaie A, Nikfar S, Abdollahi M. The place of antibiotics in management of irritable bowel syndrome: a systematic review and meta-analysis. Arch Med Sci. 2010; 6(1): 49-55.
[33] Aghili-Shirazi S. Makhzan ol advieh. Tehran: Intisharat va Amoozesh Enghelab Islami Press, 1992.
[34] Salari P, Abdollahi M. Current opinion in the pharmaceutical management of irritable and inflammatory bowel diseases: role of ATP. Recent Pat Endocr Metab Immune Drug Discov. 2009; 3(1): 69-75.
[35] Shi J, Tong Y, Shen JG, Li HX. Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: a systematic review. World J Gastroenterol. 2008; 14(3): 454-462.
[36] Shirazi S. Qarabadin-e-kabir. Tehran: Ostad Allah Qoli khan Qajar,1855.
[37] Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton L, Hungin P, Jones R, Kumar D, Rubin G, Trudgill N, Whorwell P. Guidlines on the irritable bowel syndrome: mechanisms and practical management. Gut. 2007; 56(12): 1770-1798.
[38] Nejatbakhsh F, Shirbeigi L , Rahimi R, Abolhassani H. Review of local herbal compounds found in the Iranian traditional medicine known to optimize male fertility. Andrologia. 2016; 48(8): 850-859.
[39] Tonekaboni H. Tohfat ol momenin. Tehran: Nashre Shahr Press, 2007.
[40] Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P. Redox regulation of cell survival. Antioxid Redox Signal. 2008; 10(8): 1343-1374.
[41] Thangam C, Dhananjayan R. Anti-inflammatory potential of the seeds of Carum copticum Linn. Indian J Pharmacol. 2003; 6(35): 388-391.