[1] Hart D, Craig D, Compton S, Critchlow S, Kerrigan B, McIlroy S,
Passmore AP. A retrospective study of the behavioural and psychological symptoms of mid and late phase Alzheimer's disease.
Int J Geriatr Psych. 2003; 18(11): 1037-1042.
[2] Alzheimer’s Association. Alzheimer's disease facts and figures. Alzheimers Dement. 2015; 11(3): 1-83.
[3] Desai AK, Grossberg GT. Recognition and management of behavioral disturbances in dementia. Prim Care Companion J Clin Psychiatry. 2001; 3(3): 93-109.
[4] Sadowsky CH, Galvin JE. Guidelines for the management of cognitive and behavioral problems in dementia. J Am Board Fam Med. 2012; 25(3): 350-366.
[5] Kraus CA, Seignourel P, Balasubramanyam V, Snow AL, Wilson NL, Kunik ME,
Schulz PE,
Stanley MA. Cognitive-behavioral treatment for anxiety in patients with dementia: two case studies.
J Psychiatr Pract. 2008; 14(3): 186-192.
[6] Goldsworthy MR, Vallence AM. The Role of ß-amyloid in Alzheimer’s Disease-related neurodegeneration. J Neurosci. 2013; 33(32): 12910-12911.
[7] Miguel-Hidalgo JJ, Paul IA, Wanzo V, Banerjee PK. Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β 1–40. Eur J Pharmacol. 2012; 692(1): 38-45.
[8] Kim SE, Ko IG, Kim BK, Shin MS, Cho S, Kim CJ,
Baek SS,
Lee EK,
Jee YS. Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus.
Exp Gerontol. 2010; 45(5): 357-365.
[9] Shi L, Chen J, Yang J, Pan T, Zhang S, Wang Z. MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res. 2010; 1352: 255-264.
[10] Zare N, Khalifeh S, Khodagholi F, Shahamati SZ, Motamedi F, Maghsoudi N. Geldanamycin reduces Aβ-associated anxiety and depression, concurrent with autophagy provocation. J Mol Neurosci. 2015; 57(3): 317-324.
[11] Anekonda TS, Reddy PH. Can herbs provide a new generation of drugs for treating Alzheimer's disease? Brain Res Rev. 2005; 50(2): 361-376.
[12] Kim HG, Oh MS. Herbal medicines for the prevention and treatment of Alzheimer's disease. Curr Pharm Design. 2012; 18(1): 57-75.
[13] Chashti HAK. Exir-e-Azam. 1st ed. Tehran: University of Medical Science, Institute for Islamic and Complementary Medicine, 2007.
[14] Rhazes. Al-hawi. 1st ed. Afsharipour S, (Trans.). Thehran: Academy of medical sciences publication, 2005.
[15] Avicenna. The Canon of medicine. 2nd ed. Sharafkandi A, Ed. Tehran: Soroush press, 1997.
[16] Aghili khorasani MH. Makhzan-al-advia. 1st ed. Shams Ardekani MR, Rahimi R, Farjadmand F, Eds. Tehran: Rahe kamal, 2009.
[17] Fritsch RM, Gurushidze M, Jedelska J, Keusgen M. More than apretty face-ornamental “drumstick onions” of Allium subg. melanocrommyum are also potential medicinal plants. Planta Med. 2007; 73(09): 26-59.
[18] Fritsch RM, Abbasi M. A taxonomic review of Allium subg. melanocrommyum in Iran. 1st ed. Gatersleben:IPK Gatersleben, 2013.
[19] Sobolewska D, Michalska K, Podolak I, Grabowska K. Steroidal saponins from the genus Allium. Phytochem Rev. 2016; 15(1): 1-35.
[20] Shahgholi H, Vazirimehr MRV, Hosein Talaei G, Rigi K. Effect bulb size and two specie mooseer to yield components bulb percent allicin in weather mashha. J Bio & Env Sci. 2014; 5(1):236-242.
[21] Kannappan R, Gupta SC, Kim JH, Reuter S, Aggarwal BB. Neuroprotection by spice-derived nutraceuticals: you are what you eat! Mol Neurobiol. 2011; 44(2): 142-159.
[22] Stankevičius M, Akuņeca I, Jãkobsone I, Maruška A. Analysis of phenolic compounds and radical scavenging activities of spice plants extracts. Maisto Chemija Ir Technologija. 2010; 44(2): 85-91.
[23] Ghahremani-majd H, Dashti F, Dastan D, Mumivand H, Hadian J, Esna-Ashari M. Antioxidant and antimicrobial activities of Iranian mooseer (Allium hirtifolium Boiss) populations. Hortic Environ Biote. 2012; 53(2): 116-122.
[24] Azadi HG, Ghaffari SM, Riazi GH, Ahmadian S, Vahedi F. Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Cytotechnology. 2008; 56(3): 179-185.
[25] Krejčová P, Kučerová P, Stafford GI, Jäger AK, Kubec R. Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum). J Ethnopharmacol. 2014; 154(1): 176-182.
[26] Rafieian-kopaei M, Keshvari M, Asgary S, Salimi M, Heidarian E. Potential role of a nutraceutical spice (Allium hirtifolium) in reduction of atherosclerotic plaques. J Herb Med Pharmacol. 2014; 2(2): 23-28.
[27] Mahmoodi M, Hosseini J, Hosseini-Zijoud SM, Mirzaee M, Mirzajani E. The effect of Persian shallot (Allium hirtifolium Boiss.) extract on blood sugar and serum levels of some hormones in diabetic rats. Pak J Pharm Sci. 2013; 26(2): 397-402.
[28] Jafarian A, Ghannadi A, Elyasi A. The effects of Allium hirtifolium Boiss. on cell-mediated immune response in mice. Iran J Pharm Res. 2003; 2(1): 51-55.
[29] Mohammadi S, Zarei M, Mahmoodi M, Zarei MM, Nematian MA. In vivo antinociceptive effects of Persian shallot (Allium hirtifolium) in male rat. Avicenna J Neuro Psycho Physiol. 2015; 2(1): 1-5.
[30] Hooper D, McNair JB, Field H.
Useful plants and drugs of Iran and Iraq. 1
st ed.
Chicago: Field Museum of Natural History, 1937.
[31] Ghahremaninejad F. Two new records of Astragalus species of the sections Anthylloidei DC. and Dissitiflori DC. from Iran. Turk J Bot. 2005; 29(5): 399-402.
[32] Hakim A, Tajuddin, Ghufran A, Nasreen J. Evaluation of anti-inflammatory activity of the pods of Iklil-ul-Malik (Astragalus hamosus Linn.). Indian J Nat Prod Resour. 2010; 1(1): 34-37.
[33] Shojaii A, Motaghinejad M, Norouzi S, Motevalian M. Evaluation of anti-inflammatory and analgesic activity of the extract and fractions of Astragalus hamosus in animal models. Iran J Pharm Res. 2015; 14(1): 263-269.
[34] Kondeva-Burdina M, Krasteva I, Mitcheva M. Effects of rhamnocitrin 4-β-D-galactopyranoside, isolated from Astragalus hamosus on toxicity models in vitro. Pharmacogn Mag. 2014; 10(S3): 487-493.
[35] Handa SS, Khanuja SPS, Longo G, Rakesh DD. Extraction technologies for medicinal and aromatic plants. 3rd ed. Trieste: Earth, Environmental and Marine Sciences and Technologies, 2008.
[36] National Institutes of Health. Guide for care and use of laboratory animals. 6th ed. Bethesda: NIH Publication, 1985.
[37] Bahaeddin Z, Yans A, Khodagholi F, Hajimehdipoor H, Sahranavard S. Hazelnut and neuroprotection: Improved memory and hindered anxiety in response to intra-hippocampal Aβ injection. Nutr Neurosci. In press.
[38] Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 3rd ed. San Diego: Academic Press, 2007.
[39] Walf AA, Frye CA. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2007; 2(2): 322-328.
[40] Zarrindast MR, Khalifeh S, Rezayof A, Rostami P, Sereshki AA, Zahmatkesh M. Involvement of rat dopaminergic system of nucleus accumbens in nicotine-induced anxiogenic-like behaviors.
Brain Res. 2012; 1460: 25-32.
[41] Jarskog LF, Selinger ES, Lieberman JA, Gilmore JH. Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation. Am J Psychiat. 2004; 161(1): 109-115.
[42] Porter AG, Jänicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999; 6(2): 99-104.
[43] Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000; 407(6805): 802-809.
[44] Harkany T, O'Mahony S, Keijser J, Kelly JP, Kónya C, Borostyánkői ZA,
Görcs TJ,
Zarándi M,
Penke B,
Leonard BE,
Luiten PG. β-Amyloid (1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex.
Neurobiol Dis. 2001; 8(4): 667-78.
[45] Revest J, Dupret D, Koehl M, Funk-Reiter C, Grosjean N, Piazza P,
Abrous DN. Adult hippocampal neurogenesis is involved in anxiety-related behaviors.
Mol Psychiatr. 2009; 14(10): 959-967.
[46] Hill AS, Sahay A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors. Neuropsychopharmacol. 2015; 40(10): 2368-2378.
[47] Hroudová J, Fišar Z, Raboch J. Mitochondrial functions in mood disorders. In: Kocabaşoğlu N, Ed. Mood disorders. Rijeka: InTech, 2013.
[48] Einat H, Yuan P, Manji HK. Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behav Brain Res. 2005; 165(2): 172-180.
[49] Pirbalouti AG, Ahmadzadeh Y, Malekpoor F. Variation in antioxidant, and antibacterial activities and total phenolic content of the bulbs of mooseer (Allium hirtifolium Boiss.). Acta Agric Slov. 2015; 105(1): 15-22.
[50] Galato D, Ckless K, Susin MF, Giacomelli C, Ribeiro-do-Valle RM, Spinelli A. Antioxidant capacity of phenolic and related compounds: correlation among electrochemical, visible spectroscopy methods and structure-antioxidant activity. Redox Rep. 2001; 6(4): 243-250.
[51] Montine T, Neely M, Quinn J, Beal M, Markesbery W, Roberts L, Morrow JD. Serial review: causes and consequences of oxidative stress in Alzheimer's disease. Free Radic Biol Med. 2002; 33(5): 620-626.
[52] Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules. 2010; 15(11): 7792-7814.
[53] Espín JC, García-Conesa MT, Tomás-Barberán FA. Nutraceuticals: facts and fiction. Phytochemistry. 2007; 68(22): 2986-3008.
[54] Bahadoran Z, Mirmiran P, Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord. 2013; 12(1): 1-9
[55] Gomez-Pinilla F, Nguyen TT. Natural mood foods: the actions of polyphenols against psychiatric and cognitive disorders. Nutr Neurosci. 2012; 15(3): 127-133.
[56] Dias GP, Cavegn N, Nix A, do Nascimento Bevilaqua MC, Stangl D, Zainuddin MSA, Nardi AE, Gardino PF, Thuret S. The role of dietary polyphenols on adult hippocampal neurogenesis: molecular mechanisms and behavioural effects on depression and anxiety. Oxid Med Cell Longev. 2012; Article ID 541971.
[57] Aquilano K, Baldelli S, Rotilio G, Ciriolo MR. Role of nitric oxide synthases in Parkinson’s disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res. 2008; 33(12): 2416-2426.
[58] Kim JG, Koh SH, Lee YJ, Lee KY, Kim Y, Kim S,
Lee MK,
Kim SH. Differential effects of diallyl disulfide on neuronal cells depend on its concentration.
Toxicology. 2005; 211(1): 86-96.
[59] Li XH, Li CY, Lu JM, Tian RB, Wei J. Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways. Neurosci Lett. 2012; 514(1): 46-50.
[60] Li XH, Li CY, Xiang ZG, Zhong F, Chen ZY, Lu JM. Allicin can reduce neuronal death and ameliorate the spatial memory impairment in Alzheimer's disease models. Neurosciences (Riyadh). 2010; 15(4): 237-243.
[61] Li X, Qu L, Dong Y, Han L, Liu E, Fang S, Zhang Y, Wang T. A Review of recent research progress on the Astragalus genus. Molecules. 2014; 19(11): 18850-18880.
[62] Krasteva I, Platikanov S, Nikolov S, Kaloga M. Flavonoids from Astragalus hamosus. Nat Prod Res. 2007; 21(5): 392-395.
[63] Cardoso BR, Ong TP, Jacob-Filho W, Jaluul O, Freitas MIdÁ, Cozzolino SMF. Nutritional status of selenium in Alzheimer's disease patients. Brit J Nutr. 2010; 103(06): 803-806.
[64] Shaw W, Anderson J. Comparative enzymology of the adenosine triphosphate sulphurylases from leaf tissue of selenium-accumulator and non-accumulator plants. Biochem J. 1974; 139(1): 37-42.
[65] Cao C, Wang L, Lin X, Mamcarz M, Zhang C, Bai G, Bai G,
Nong J,
Sussman S,
Arendash G. Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice.
J Alzheimers Dis. 2011; 25(2): 323-335.