[1] OECD: Onunkwo GC, Akah PA, Udeala OK. Studies on Bridelia ferruginea leaves. Stability and hypoglycemic actions of the leaf extract tablets. Phytopther Res. 1996; 10(5): 418-420.
[2] Olajide OA, Makinde JM, Okpako DT, Awe SO. Studies on the antiinflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark. J Ethnopharmacol. 2007; 71(1-2): 153-160.
[3] Njamen D, Nkeh-Chungag BN, Tsala E, Fomum ZT, Mbanya JC, Ngufor GF. Effect of Bridelia ferruginea (Euphorbiaceae) leaf extract on sucrose-induced glucose intolerance in rats. Trop J Pharm Res. 2012; 11(5): 759-765.
[4] Hilaly JE, Isaili ZH, Lyoussi B. Acute and chronic toxicological studies of Ajuva iva in experimental animals. J Ethnopharmacol. 2004; 91(1): 43-50.
[5] Sahoo N, Manchikanti P, Dey S. Herbal drugs: standards and regulation. Fitoterapia. 2010; 81(6): 462-471.
[6] Bouquet A, Debray M. Plantes médicinales de la Côte d’ivoire. Paris : Travaux de l’ORSTOM (32), 1974.
[7] Bakoma B, Eklu-Gadegkeku K, Agbonon A, Aklikoku K, Bassene E, Gbeassor M. Preventive effect of Bridelia ferruginea against high fructose diet induced tolerance, oxidative stress and hyperlipidamia in male wistar rats. J Pharmacol Toxicol. 2011; 6(3): 249 - 257.
[8] Nene-Bi SA, Zahoui OS, Soro TY, Traore F. Diuretic and natriuretic activity of an aqueous extract of Bridelia Ferruginea Benth. (Euphorbiaceae) in normal rats. J Phys Pharm Adv. 2012; 2(10): 349-353.
[9] Nene-Bi SA, Priya P, Jitendra SK, Babu NK, Sanjay CR, Brijesh K, Yadav PP, Traore F, Jagavelu K, Madhu D. Vasomodulatory effects and mass spectral analysis of Bridelia ferruginea Benth. Indian J Exp Biol. 2018; 56(9): 621-628.
[10] Néné-Bi SA, Soro TY, Zahoui OS, Traoré F. Effet d’une administration aiguë d’un extrait aqueux de Bridelia ferruginea Benth. (Euphorbiaceae) sur la fonction rénale chez le rat. Phytotherapie. 2013; 11(6): 359-364.
[11] Nene-Bi SA, Traore F, Soro TY, Souza A. Etudes phytochimique et pharmacologique de Bridelia ferruginea Benth. (Euphorbiaceae) sur la motricité du Taenia coli de cobaye. Afr Sci Rev Int Sci Technol. 2009; 5(2): 305-320.
[12] Nene-Bi SA, Ramachandran V, Vengal RP, Gopalakrishnan R, Dhanabal SP, Traore F. Subchronic toxicity studies of the aqueous stem bark extract of Bridelia ferruginea in Wistar rats. Bull Env Pharmacol Life Sci. 2016; 5(10): 14-21.
[13] Adesina AJ, Akomolafe SF. Nutritional and anti-nutritional composition of Bridelia ferruginea Benth. (Euphorbiaceae) stem bark sample. Int J Sci Knowl. 2014; 2(2): 92-104.
[14] R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. [Accessed 2020]. https://www.R-project.org/.
[15] Gorzinski SJ, Kociba RJ, Campbell RA, Smith FA, Nolan RJ, Eisenbrandt DL. Acute, pharmacokinetic, and subchronic toxicological studies of 2,4-dichlorophenoxyacetic acid. Food Appl Toxicol. 1987; 9(3): 423-435.
[16] Timchalk C. Comparative inter-species pharmacokinetics of phenoxyacetic acid herbicides and related organic acids. Evidence that the dog is not a relevant species for evaluation of human health risk. Toxicology. 2004; 200(1): 1-19.
[17] Maronpot RR, Koyanagi M, Davis J, Recio L, Marbury D, Boyle M, Hayashi SM. Safety assessment and single-dose toxicokinetics of the flavouring agent myricitrin in Sprague-Dawley rats. Food Addit Contam Part A. 2015; 32(11): 1799-1809.
[18] Giudicelli JF, Tillement JP. Influence of sex on drug kinetics in man. Clin Pharmacokinet. 1977; 2(3): 157-166.
[19] Mugford CA, Kedderis GL. Sex-dependent metabolism of xenobiotics. Drug Metab Rev. 1998; 30(3): 441-498.
[20] Acosta-Martinez M, Horton T, Levine JE. Estrogen receptors in neuropeptide Y neurons: at the crossroads of feeding and reproduction. Trends Endocrinol Metab. 2007; 18(2): 48-50.
[21] Ghosh D, Mondal S, Ramakrishna K. Acute and sub-acute (30-day) toxicity studies of Aegialitis rotundifolia Roxb. leaves extract in Wistar rats: safety assessment of a rare mangrove traditionally utilized as pain antidote. Clin Phytosci. 2019; 5(1): 1-16.
[22] Venkatesan PS, Deecaraman M, Vijayalakshmi M, Sakthivelan SM. Sub-acute toxicity studies of acetaminophen in Sprague Dawley rats. Biol Pharm Bull. 2014; 37(7): 1184-1190.
[23] Akuodor GC, Mbah CC, Anyalewechi NA, Idris-Usman M, Iwuanyanwu TC, Osunkwo UA. Pharmacological profile of aqueous extract of Bridelia ferruginea stem bark in the relief of pain and fever. J Med Plant Res. 2011; 5(22): 5366-5369.
[24] OECD guidance document on the recognition, assessment and use of clinical signs as humane endpoints for experimental animals used in safety evaluation environmental health and safety monograph series on testing and assessment No 19. 2000. [Accessed 2020]. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2000)7&doclanguage=en.
[25] Lipnick RL, Cotruvo JA, Hill RN, Bruce RD, Stitzel KA, Walker AP, Chu I, Goddard M, Segal L, Springer JA, Myers RC. Comparison of the up-and down, conventional LD50, and fixed dose acute toxicity procedures. Food Chem Toxicol. 1995; 33(3): 223-231.
[26] Tarttelin MF, Gorski RA. Variations in food and water intake in the normal and acyclic female rat. Physiol Behav. 1971; 7(6): 847-852.
[27] Shimizu H, Bray GA. Effects of castration, estrogen replacement and estrus cycle on monoamine metabolism in the nucleus accumbens, measured by microdialysis. Brain Res. 1993; 621(2): 200-206.
[28] Fukushima A, Hagiwara H, Fujioka H, Kimura F, Akema T, Funabashi T. Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus. Front Neurosci. 2015; 9(1): 1-7.
[29] Clegg DJ, Riedy CA, Blake Smith KA, Benoit SC, Woods SC. Differential sensitivity to central leptin and insulin in male and female rats. Diabetes. 2003; 52(3): 682-687.